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Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence
https://repo.qst.go.jp/records/44129
https://repo.qst.go.jp/records/44129e8f8b26e-d697-4a06-b152-617dbf04ddd5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-31 | |||||
| タイトル | ||||||
| タイトル | Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Okamoto, Mieko× Nishimura, Mayumi× Nishimura, Yukiko× Ootawara, Masami× Kakinuma, Shizuko× Tokairin, Yutaka× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 西村 由希子× 太田原 雅美× 柿沼 志津子× 東海林 裕× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The ApcMin/+ (Min) mouse is a genetically predisposed model of both intestinal and mammary tumorigenesis. We investigated age-related changes in the susceptibility to radiation-induced mammary tumorigenesis using this model. Female Min and wild-type mice having the C57BL/6J background were irradiated with 2 Gy of X-rays at 2, 5, 7 and 10 weeks and sacrificed at 18 weeks of age. Min mice irradiated at 7-10 weeks of age developed mammary tumors with squamous metaplasia, whereas their wild-type littermates did not. Interestingly, irradiation of Min mice at 2-5 weeks did not induce mammary tumors but rather cystic nodules with metaplasia. The mammary tumors exhibited increased nuclear beta-catenin protein and loss of the wild-type Apc allele. Our results show that susceptibility to radiation-induced mammary tumorigenesis increases with age in Min mice, suggesting that the tumorigenic effect of ionizing radiation targets the lobular-alveolar progenitor cells, which increase in number with age and are controlled by beta-catenin signaling. | |||||
| 書誌情報 |
Radiation Research 巻 165, p. 165-173, 発行日 2006 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
