{"created":"2023-05-15T14:34:03.109041+00:00","id":44129,"links":{},"metadata":{"_buckets":{"deposit":"57ef3d16-685f-48b4-9923-7524acc8637e"},"_deposit":{"created_by":1,"id":"44129","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44129"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044129","sets":["1"]},"author_link":["438608","438617","438614","438619","438609","438620","438611","438621","438622","438610","438613","438612","438615","438616","438618"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"173","bibliographicPageStart":"165","bibliographicVolumeNumber":"165","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ApcMin/+ (Min) mouse is a genetically predisposed model of both intestinal and mammary tumorigenesis. We investigated age-related changes in the susceptibility to radiation-induced mammary tumorigenesis using this model. Female Min and wild-type mice having the C57BL/6J background were irradiated with 2 Gy of X-rays at 2, 5, 7 and 10 weeks and sacrificed at 18 weeks of age. Min mice irradiated at 7-10 weeks of age developed mammary tumors with squamous metaplasia, whereas their wild-type littermates did not. Interestingly, irradiation of Min mice at 2-5 weeks did not induce mammary tumors but rather cystic nodules with metaplasia. The mammary tumors exhibited increased nuclear beta-catenin protein and loss of the wild-type Apc allele. Our results show that susceptibility to radiation-induced mammary tumorigenesis increases with age in Min mice, suggesting that the tumorigenic effect of ionizing radiation targets the lobular-alveolar progenitor cells, which increase in number with age and are controlled by beta-catenin signaling.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"438608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, Mieko"}],"nameIdentifiers":[{"nameIdentifier":"438609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"438610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"438611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ootawara, Masami"}],"nameIdentifiers":[{"nameIdentifier":"438612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"438613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokairin, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"438614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"438615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 由希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田原 雅美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東海林 裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438622","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-05-31"},"publish_date":"2006-05-31","publish_status":"0","recid":"44129","relation_version_is_last":true,"title":["Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:19:04.064180+00:00"}