WEKO3
アイテム
Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4
https://repo.qst.go.jp/records/44054
https://repo.qst.go.jp/records/440542d086213-a09c-41c6-b57e-c359c137e34f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-04-19 | |||||
| タイトル | ||||||
| タイトル | Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuji, Atsushi
× Tsuji, Atsushi× Sugyo, Aya× Sudou, Hitomi× Sagara, Masashi× Ishikawa, Atsuko× Ohtuki, Marika× Kimura, Tomo× Ogiu, Toshiaki× Miyagishi, Makoto× Taira, Kazunari× Imai, Takashi× Harada, Yoshinobu× 辻 厚至× 須尭 綾× 須藤 仁美× 相良 雅史× 石川 敦子× 大月 まり香× 菅 智× 荻生 俊昭× 今井 高志× 原田 良信 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Long Evans cinnamon (LEC) rat is highly susceptible to X-irradiation due to defective DNA repair and is thus a model for hepatocellular carcinogenesis. We constructed a bacterial artificial chromosome (BAC) contig of rat chromosome 4 completely covering the region associated with radiation susceptibility. We used transient and stable transfections to demonstrate that defective DNA repair in LEC cells is fully complemented by a 200-kb BAC, CHORI-230-65K18. Further analysis showed that the region associated with radiation susceptibility is located in a 128,543-bp region of 65K18 that includes the known gene Rpn1. However, neither knockdown nor overexpression of Rpn1 indicated that this gene is associated with radiation susceptibility. We also mapped three ESTs (TC523872, TC533727, and CB607546) in the 128,543-bp region, suggesting that 65K18 contains an unknown gene associated with X-ray susceptibility in the LEC rat. | |||||
| 書誌情報 |
Genomics 巻 87, 号 2, p. 236-242, 発行日 2006-02 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0888-7543 | |||||
