@article{oai:repo.qst.go.jp:00044054,
 author = {Tsuji, Atsushi and Sugyo, Aya and Sudou, Hitomi and Sagara, Masashi and Ishikawa, Atsuko and Ohtuki, Marika and Kimura, Tomo and Ogiu, Toshiaki and Miyagishi, Makoto and Taira, Kazunari and Imai, Takashi and Harada, Yoshinobu and 辻 厚至 and 須尭 綾 and 須藤 仁美 and 相良 雅史 and 石川 敦子 and 大月 まり香 and 菅 智 and 荻生 俊昭 and 今井 高志 and 原田 良信},
 issue = {2},
 journal = {Genomics},
 month = {Feb},
 note = {The Long Evans cinnamon (LEC) rat is highly susceptible to X-irradiation due to defective DNA repair and is thus a model for hepatocellular carcinogenesis. We constructed a bacterial artificial chromosome (BAC) contig of rat chromosome 4 completely covering the region associated with radiation susceptibility. We used transient and stable transfections to demonstrate that defective DNA repair in LEC cells is fully complemented by a 200-kb BAC, CHORI-230-65K18. Further analysis showed that the region associated with radiation susceptibility is located in a 128,543-bp region of 65K18 that includes the known gene Rpn1. However, neither knockdown nor overexpression of Rpn1 indicated that this gene is associated with radiation susceptibility. We also mapped three ESTs (TC523872, TC533727, and CB607546) in the 128,543-bp region, suggesting that 65K18 contains an unknown gene associated with X-ray susceptibility in the LEC rat.},
 pages = {236--242},
 title = {Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4},
 volume = {87},
 year = {2006}
}