WEKO3
アイテム
Radiation-Induced Apoptosis in Peritoneal Resident Macrophages of C3H Mice
https://repo.qst.go.jp/records/43609
https://repo.qst.go.jp/records/436099e086595-96da-4ca0-8035-f74d51e76c26
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-01-11 | |||||
| タイトル | ||||||
| タイトル | Radiation-Induced Apoptosis in Peritoneal Resident Macrophages of C3H Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kubota, Yoshihisa
× Kubota, Yoshihisa× Takahashi, Sentaro× Sato, Hiroshi× Suetomi, Katsutoshi× Aizawa, Shirou× 久保田 善久× 高橋 千太郎× 佐藤 宏× 末冨 勝敏× 相澤 志郎 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gamma ray-radiation induced significant apoptosis in peritoneal resident macrophages (PRMs) of C3H/HeJ (C3H) mice, but not other strains of mice. In order to investigate the role of DNA damage in the apoptosis, DNA damage was quantified in PRMs using the alkaline single cell gel electrophoresis (Comet) assay. No significant difference was found between C3H and C57Black/6 mice in either radiation-induced DNA damage or repair. Radiation induced apoptosis at the same level in PRMs of p53 knockout mice and atm knockout mice as in those of wild type C3H mice, however radiation-induced apoptosis was significantly less extensive in thymocytes of these mutant mice than those of wild type mice. Apoptosis was also induced at the same level by irradiation in PRMs of C3H scid mice as in those of wild type C3H mice. Therefore, it was suggested that radiation-induced DNA damage and TP53, ATM or DNA-PK mediated cellular responses occurring downstream thereof were not involved in the radiation-induced apoptotic cell death in C3H mouse PRMs. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 45, 号 2, p. 205-211, 発行日 2004 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
