@article{oai:repo.qst.go.jp:00043609,
 author = {Kubota, Yoshihisa and Takahashi, Sentaro and Sato, Hiroshi and Suetomi, Katsutoshi and Aizawa, Shirou and 久保田 善久 and 高橋 千太郎 and 佐藤 宏 and 末冨 勝敏 and 相澤 志郎},
 issue = {2},
 journal = {Journal of Radiation Research},
 month = {},
 note = {Gamma ray-radiation induced significant apoptosis in peritoneal resident macrophages (PRMs) of C3H/HeJ (C3H) mice, but not other strains of mice. In order to investigate the role of DNA damage in the apoptosis, DNA damage was quantified in PRMs using the alkaline single cell gel electrophoresis (Comet) assay. No significant difference was found between C3H and C57Black/6 mice in either radiation-induced DNA damage or repair. Radiation induced apoptosis at the same level in PRMs of p53 knockout mice and atm knockout mice as in those of wild type C3H mice, however radiation-induced apoptosis was significantly less extensive in thymocytes of these mutant mice than those of wild type mice. Apoptosis was also induced at the same level by irradiation in PRMs of C3H scid mice as in those of wild type C3H mice. Therefore, it was suggested that radiation-induced DNA damage and TP53, ATM or DNA-PK mediated cellular responses occurring downstream thereof were not involved in the radiation-induced apoptotic cell death in C3H mouse PRMs.},
 pages = {205--211},
 title = {Radiation-Induced Apoptosis in Peritoneal Resident Macrophages of C3H Mice},
 volume = {45},
 year = {2004}
}