量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Research on induction of adaptive response (AR) is expected to contribute to the risk estimation, practical applications to active induction of radioresistance and to cancer therapy, and mechanism of heavy ion irradiations. In a series of investigation, induction of AR by combination of irradiation with different LET values was attempted in a series of investigations in young adult female mice of C57BL/6J strain using thirty-day survival test as main endpoint. For total body irradiations, X-rays and high LET accelerated heavy ion irradiations including carbon, silicon, neon and iron particles were used. Significant suppression of mouse death was used as a criterion for judgment of a successful AR induction. In the past 6 years, twenty-three combinations were performed. Results showed that induction of AR is an event depending on the LET or/and species of the ions. Generally, it is hardly to induce AR by X-rays against heavy ion irradiations with very high LET values, and high LET heavy ion irradiations hardly induce AR against X-rays or higher LET heavy ion irradiations. As the mechanism under low LET X-ray-induced AR is the induced resistance in the hematopoietic system, these findings would provide a new insight into further mechanistic study on radiation-induced AR. In the present presentation, these findings will be reported. In addition, recent work on the responses in the hematopoietic system under AR-inducible and AR-uninducible conditions will be discussed.
Study on Heavy-ion-irradiation-induced Adaptive Response in Mice
