量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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We have tested radiobiological effects of a microplaner beam having ten 20 um widths every 200 um at Spring-8. We measured tumor growth delay (TGD) of transplanted NFSa tumor and normal skin reaction score (SRS) on C3H. Mice were preconditioned 8 days before irradiation in NIRS, and shipped to irradiation site. They were held on a plastic board under anesthesia, and areas of tumor or depilated skin were irradiated. They were shipped again to Kitasato University in Aomori, and measured TGD and SRS. We measured periods that tumors grown to be 5 times bigger than that at the day of irradiation. It took 5.5 days for unirradiated group, and 10.5 days for 800 Gy irradiated groups. The TGD increased linearly with the dose, and no increment of the tumor volume was observed in some mice when they received 1200 or 1600 Gy. The SRS increased linearly with days, and reached maxima at around 2 weeks after the irradiation. Slight moist desquamation (skin score 3.0) was found at 1600 Gy irradiated group.
Radiobiological pilot study of synchrotron generated microplaner beam, a possible modality of radiotherapy
