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LET dependence of oxidative DNA base damage in 2-deoxyguanine aqueous solution irradiated with heavy ions
https://repo.qst.go.jp/records/62689
https://repo.qst.go.jp/records/62689fe2e5a25-fea9-4596-b10a-acb71df754a3
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-09-02 | |||||
タイトル | ||||||
タイトル | LET dependence of oxidative DNA base damage in 2-deoxyguanine aqueous solution irradiated with heavy ions | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Furusawa, Yoshiya× Murayama, Chieko× Kusano, Yohsuke× Ito, Atsushi× 平山 亮一× 古澤 佳也× 村山 千恵子× 伊藤 敦 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To evaluate the contribution of indirect action mediated by OH radicals in biological effects of high LET radiations, we examined the production of 8-hydroxy-2-deoxyguanosine (8-OHdG) in 2-deoxyguanosine aqueous solution using various ion species with an LET range from 20 to 300 keV/mm. The 8-OHdG yield decreased with increasing LET. In the hypoxic irradiation condition, the yield showed constant or rather increasing tendency above about 100 keV/mm, which is consistent with an oxygen-in-the-track hypothesis to explain the diminishment of oxygen effect. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The 2nd Asia-Pacific Symposium on Radiation Chemistry (APSRC-2008) | |||||
発表年月日 | ||||||
日付 | 2008-09-01 | |||||
日付タイプ | Issued |