量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Abstract
CHO cells and deficient cells in non-homologous end joining (NHEJ) and in homologous recombination (HR) were irradiated with X-rays, 15 keV/µm carbon-ions and 200 keV/µm iron-ions, and the dose-response survival curves on these cells were compared. For CHO and HR-deficient 51D1 cells, exposure to iron-ions yielded the lowest cell survival, followed by carbon-ions and then X-rays. NHEJ-deficient xrs6 cells showed no difference ( or small) of cell survival for X-, carbon- and iron-ion irradiation under oxic condition. OER values for 51D1 were smaller than that for CHO and xrs6 cells.
Tumors of SCCVII cells in one group of mice were made hypoxic by clamping before irradiation with carbon and iron-ions of the LET range from 15 to 200 keV/µm, whereas those in another group received irradiation without clamping. Mice received either single-dose or two fractionated doses with a fixed interval of 24 h for 2 days. Cell survivals were determined by in vivo-in vitro colony formation. We could see the repair/recovery from the damage from carbon-ions under both oxic and hypoxic conditions. However, we couldn’t see the difference between single-dose and two fractionated doses for iron-ion irradiation under oxic and hypoxic conditions.
雑誌名
2012 Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC
重粒子線による有・低酸素環境下でのRBEならびにOER（12J468）
