量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Objectives: To determine the potential utility of the frontal assessment battery (FAB)
in assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated
the association between the FAB score and regional gray matter volume, and
ascertained whether the regional brain alterations related to cognitive impairments
occur in relatively mild stage of ALS.
Materials and Methods: Twenty-four
ALS patients with a Mini-Mental
State
Examination score of >23, a normal score on the Self-Rating
Depression Scale, little or
no disturbance in speech and handling utensils on the ALS Functional Rating Scale
(ALSFRS), and normal measures on respiratory tests (respiratory function test and arterial
blood gas analysis), and two age-matched
normal control groups (one for FAB
assessment and the other for brain morphometry) underwent FAB testing and structural
magnetic resonance imaging. We applied voxel-based
morphometry to investigate
the relationship between the FAB score and regional brain alteration, and
assessed the relationship between the altered regional brain volume and ALSFRS or
respiratory tests.
Results: Frontal assessment battery scores were significantly lower in ALS patients
than in normal controls. Volume reduction in the right orbitofrontal gyrus in ALS was
correlated with a lower FAB score. There was no correlation between the right orbitofrontal
gyrus volume and ALSFRS or respiratory tests.
Conclusions: The results suggest that the FAB is an adequate tool for detecting cognitive
impairments related to frontal lobe pathology in the relatively mild stage of ALS,
independent of physical dysfunctions.
Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
