{"created":"2023-05-15T14:37:44.015046+00:00","id":48678,"links":{},"metadata":{"_buckets":{"deposit":"1794da1f-9eb3-48f4-ab03-5b4909e5ad1e"},"_deposit":{"created_by":1,"id":"48678","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48678"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048678","sets":["1"]},"author_link":["489752","489750","489754","489757","489756","489755","489749","489751","489753"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"e00707","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Brain and Behavior"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: To determine the potential utility of the frontal assessment battery (FAB)\nin assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated\nthe association between the FAB score and regional gray matter volume, and\nascertained whether the regional brain alterations related to cognitive impairments\noccur in relatively mild stage of ALS.\nMaterials and Methods: Twenty-four\nALS patients with a Mini-Mental\nState\nExamination score of >23, a normal score on the Self-Rating\nDepression Scale, little or\nno disturbance in speech and handling utensils on the ALS Functional Rating Scale\n(ALSFRS), and normal measures on respiratory tests (respiratory function test and arterial\nblood gas analysis), and two age-matched\nnormal control groups (one for FAB\nassessment and the other for brain morphometry) underwent FAB testing and structural\nmagnetic resonance imaging. We applied voxel-based\nmorphometry to investigate\nthe relationship between the FAB score and regional brain alteration, and\nassessed the relationship between the altered regional brain volume and ALSFRS or\nrespiratory tests.\nResults: Frontal assessment battery scores were significantly lower in ALS patients\nthan in normal controls. Volume reduction in the right orbitofrontal gyrus in ALS was\ncorrelated with a lower FAB score. There was no correlation between the right orbitofrontal\ngyrus volume and ALSFRS or respiratory tests.\nConclusions: The results suggest that the FAB is an adequate tool for detecting cognitive\nimpairments related to frontal lobe pathology in the relatively mild stage of ALS,\nindependent of physical dysfunctions.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28638712","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/brb3.707","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://onlinelibrary.wiley.com/doi/10.1002/brb3.707/full"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://onlinelibrary.wiley.com/doi/10.1002/brb3.707/full","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2162-3279","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Terada, Tatsuhiro"}],"nameIdentifiers":[{"nameIdentifier":"489749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyata, Jun"}],"nameIdentifiers":[{"nameIdentifier":"489750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Obi, Tomokazu"}],"nameIdentifiers":[{"nameIdentifier":"489751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"489752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshizumi, Miho"}],"nameIdentifiers":[{"nameIdentifier":"489753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Kinya"}],"nameIdentifiers":[{"nameIdentifier":"489754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoguchi, Kouichi"}],"nameIdentifiers":[{"nameIdentifier":"489755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murai, Toshiya"}],"nameIdentifiers":[{"nameIdentifier":"489756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保田 学","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489757","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-08"},"publish_date":"2018-04-08","publish_status":"0","recid":"48678","relation_version_is_last":true,"title":["Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:25:31.262462+00:00"}