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Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device.
https://repo.qst.go.jp/records/47149
https://repo.qst.go.jp/records/47149fd4c2192-34bb-43a1-a6e6-47aac1e8a404
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-07-15 | |||||
タイトル | ||||||
タイトル | Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Sasaki, Naoki
× Sasaki, Naoki× Jo, Jun-ichiro× Aoki, Ichio× Sato, Kae× 青木 伊知男 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We report a microvascular-interstitium model on microfluidic devices to study leakage of drugs from blood vessels under in vivo-like flow conditions. We employed magnetic resonance imaging to demonstrate the compatibility of the model for experimental animals and humans. We observed transport of two types of different molecular-weight contrast agents into the model interstitium. The ratio of the transport rates of agents agreed with the ratio calculated from diffusion coefficients of the agents. We expect that the model will be useful for the estimation and evaluation of leakage of many kinds of agents in vivo. | |||||
書誌情報 |
Analytical biochemistry 巻 458, p. 72-74, 発行日 2014-08 |
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出版者 | ||||||
出版者 | Academic Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0003-2697 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24708939 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ab.2014.03.020 |