@article{oai:repo.qst.go.jp:00047149, author = {Sasaki, Naoki and Jo, Jun-ichiro and Aoki, Ichio and Sato, Kae and 青木 伊知男}, journal = {Analytical biochemistry}, month = {Aug}, note = {We report a microvascular-interstitium model on microfluidic devices to study leakage of drugs from blood vessels under in vivo-like flow conditions. We employed magnetic resonance imaging to demonstrate the compatibility of the model for experimental animals and humans. We observed transport of two types of different molecular-weight contrast agents into the model interstitium. The ratio of the transport rates of agents agreed with the ratio calculated from diffusion coefficients of the agents. We expect that the model will be useful for the estimation and evaluation of leakage of many kinds of agents in vivo.}, pages = {72--74}, title = {Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device.}, volume = {458}, year = {2014} }