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量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Permalink : http://id.nii.ac.jp/1657/00044074/

Localization of Indium-111 in Human Malignant Tumor Xenografts and Control by Chelators 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Watanabe Naoyuki Oriuchi Noboru Endou Keigo Inoue Tomio Tanada Shuji Murata Hajime Sasaki Yasuhito et.al
抄録	The kinetics of soluble indium-111(111In) in human malignant tumor xenografts and cells was investigated in combination with chelators. Firstly, without chelator, the kinetics of 111In-choride was investigated in vitro and in vivo using four human malignant neuroblastoma SK-N-MC, pulmonary papillary adenocarcinoma NCI-H441, pulmonary squamous cell carcinoma PC9, and colon adenocarcinoma LS180 cells and xenografts. 111In was incorporated into tumor cells in vitro to a maximum level during a 60-min incubation. A maximum level of radioactivity was demonstrated in vivo in four human malignant tumors xenografted into nude mice at 24 h postinjection of 111In-chloride. Secondly, the effect of edetate calcium disodium (CaNa2EDTA) on radioactivity in 111In-labeled tumors xenografts and cells was studied in vitro and in vivo. CaNa2EDTA significantly reduced 111In-activity from the laveled tumor xenografts, whereas it had no affect on hte radioactivity in the labeled cells. Thirdly, the effect of CaNa2EDA on radioactivity in human malignant tumors xenografted into nude mice injected with 111In-chloride was investigated. In one group of mice CaNa2EDTA administered intraperioneally at 1,22,34,46,58, and 70 h after injection of 111In-chloride (postadministration), the localization of 111In at the tumors was significantly decreased at 72 h compared with the control in all four tumor types. In the other group of mice, CaNa2EDTA administered intraperitoneally at 12 and 1 h before injection of 111In-chloride and 1,22,34,46,58, and 70 h postinjection (pre- and postadministration), the radioactivity of tumors was also significantly decreased at 72 h, and the reduction was greater than that with use of postadministration. In a comparative study, CaNa3DTPA had a more powerful effect than CaNa2EDTA. In conclusion, 111In-activity in tumors consists of intracellular and extracellular components, and the extracellular 111In may be cleared by chelators. Pre- and postadministration of CaNa3DTPA could remove 111In-nonspecific localization in tumors when 111In is released from the radiolaveled agents.
雑誌名	Nuclear Medicine and Biology
巻	26
号	7
ページ	853 - 858
発行年	1999
ISSN	0969-8051
著者版フラグ	none

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