{"created":"2023-05-15T15:03:43.466508+00:00","id":86268,"links":{},"metadata":{"_buckets":{"deposit":"40454c70-a10c-4309-a102-3b9938d70380"},"_deposit":{"created_by":1,"id":"86268","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"86268"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00086268","sets":["10:29"]},"author_link":["1050801","1050793","1050797","1050800","1050803","1050804","1050806","1050787","1050798","1050792","1050795","1050802","1050789","1050791","1050805","1050790","1050794","1050799","1050788","1050796"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-09-11","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は遺伝子レポーターPETトレーサーとして[11C]トリメトプリム(TMP)と[18F]フルオロエトキシ-TMPを開発し、マウスとマーモセットの脳に発現させたE.coli dihydrofolate reductase(ecDHFR)を画像化してきた[1]。今回、新たに[18F]フルオロヒドロキシプロピルオキシ(FHP)-TMPを合成し、インビトロとインビボの評価を行った。標識合成は当施設で開発した自動合成装置を用い、[18F]フルオロアルキル試薬である[18F]エピフルオロヒドリンをフェノール前駆体と反応させた。その結果、[18F]FHP-TMPが収率13％(18F-より計算)と放射化学純度98%以上で得られた。一方、分子動力学計算により、ecDHFRのリガンド結合部位にFHP-TMPがフィットする複合体が得られた。また、標識した[18F]FHP-TMPのecDHFRに対するKdは50.8nMであった。現在、PETイメージングを含めた評価を行なっており、結果は当日発表予定である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第62回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大久保, 崇之"}],"nameIdentifiers":[{"nameIdentifier":"1050787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下條, 雅文"}],"nameIdentifiers":[{"nameIdentifier":"1050788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 麻衣子"}],"nameIdentifiers":[{"nameIdentifier":"1050789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"1050790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"1050791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"1050792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永井, 裕司"}],"nameIdentifiers":[{"nameIdentifier":"1050793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南本, 敬史"}],"nameIdentifiers":[{"nameIdentifier":"1050794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"1050795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"1050796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masafumi, Shimojo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maiko, Ono","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Fujinaga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanao, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuki, Nengaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuji, Nagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takafumi, Minamimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050806","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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