{"created":"2023-05-15T15:03:39.920331+00:00","id":86215,"links":{},"metadata":{"_buckets":{"deposit":"328976f3-ac6e-46ac-9b5b-83f6008a5126"},"_deposit":{"created_by":1,"id":"86215","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"86215"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00086215","sets":["10:29"]},"author_link":["1050268","1050269","1050270","1050267","1050266","1050265"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-05-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chemodynamic therapy (CDT) that generate reactive oxygen species (ROS) and causes oxidative damage to tumor cells shows tremendous promise for　advanced cancer treatment. Herein, we report a multifunctional nanoprobe (BCGCR) integrating bimodal imaging and photothermalenhanced CDT of　targeted tumor, which is produced by covalent conjugation of bovine serum 　albumin-stabilized CuS/Gd2O3 nanoparticles with Cy5.5 fluorophore and tumor-targeting ligand RGD. It was used for both sensitive fluorescence imaging and high-spatial-resolution magnetic resonance imaging of tumor in vivo. Moreover, owing to the strong NIR absorbance from internal CuS NPs, BCGCR can generate localized heat under 980 nm laser irradiation, which enables photothermal therapy (PTT) and further intensifies ROS generation for enhanced CDT. This synergetic effect takes on such an excellent therapeutic efficacy that it can ablate xenografted tumors in vivo. ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"量子生命科学会第4回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Minchuan, Luo"}],"nameIdentifiers":[{"nameIdentifier":"1050265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Onoshima, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"1050266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Yukawa"}],"nameIdentifiers":[{"nameIdentifier":"1050267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinobu, Baba"}],"nameIdentifiers":[{"nameIdentifier":"1050268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Yukawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinobu, Baba","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050270","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal  Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of  Targeted Tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal  Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of  Targeted Tumors"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-30"},"publish_date":"2022-05-30","publish_status":"0","recid":"86215","relation_version_is_last":true,"title":["Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal  Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of  Targeted Tumors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:09:00.745457+00:00"}