@article{oai:repo.qst.go.jp:00086181,
 author = {Soon Chan, Wai and Kumar, Amarjeet and Hidetoshi, Kono and Soon Chan, Wai and Kumar, Amarjeet and Hidetoshi, Kono},
 journal = {Trends in Genetics},
 month = {May},
 note = {The current understanding of how specific distributions of histone posttranslational modifications (PTMs) are achieved throughout the chromatin
remains incomplete. This review focuses on the role of RNA polymerase II (RNAPII) in establishing H2BK120/K123 ubiquitination and H3K4/K36 methylation distribution. The rate of RNAPII transcription is mainly a function of the RNAPII elongation and recruitment rates. Two major mechanisms link RNAPII’s transcription rate to the distribution of PTMs. First, the phosphorylation patterns of Ser2P/Ser5P in the C-terminal domain of RNAPII change as a function of time, since the start of elongation, linking them to the elongation rate. Ser2P/Ser5P recruits specific histone PTM enzymes/activators to the nucleosome. Second, multiple rounds of binding and catalysis by the enzymes are required to establish higher methylations (H3K4/36me3). Thus, methylation states are determined by the transcription rate. In summary, the first mechanism determines the location of methylations in the gene, while the second mechanism determines the methylation state.},
 title = {RNAPII driven post-translational modifications of nucleosomal histones},
 year = {2022}
}