{"created":"2023-05-15T15:03:35.356302+00:00","id":86145,"links":{},"metadata":{"_buckets":{"deposit":"2c803cc3-881e-4835-8bb0-058391c6b6b8"},"_deposit":{"created_by":1,"id":"86145","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"86145"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00086145","sets":["10:29"]},"author_link":["1046688","1046697","1046686","1046699","1046694","1046680","1046684","1046685","1046683","1046696","1046698","1046682","1046691","1046692","1046693","1046687","1046695","1046690","1046689","1046681"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-09-11","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景・目的】ADPM06はaza-BODIPY類であり、光線力学療法（PDT）用の光感受性物質として開発された。ADPM06を用いたPDTでは、様々な腫瘍モデルにおいて短時間近赤外レーザー照射により腫瘍の縮退効果がみられた。我々は、ADPM06の安全性を評価するために、18Fを標識したADPM06を開発し、インビボ評価を行った。\n【方法】[18F]ADPM06は、同位体交換反応を用いて合成を行った。18F-はSepPak QMAからテトラブチルアンモニウムを用いて溶出し、乾燥後、塩化スズ（IV）入りADPM06アセトニトリル溶液中で室温10分間反応させ、18Fを標識した。インビボ実験はマウスを用いて体内動態を評価した。\n【結果】[18F]ADPM06は18F標識自動合成装置を用い、合成時間60分程度、10％程度の放射化学的収率で合成でき、注射液とした。[18F]ADPM06投与後のマウス体内放射能分布は、測定可能な全ての臓器において、投与後120分まで初期取り込みの後に徐々に減少した。\n【結論】[18F]ADPM06を注射液として合成でき、体内動態をインビボで評価することができた。\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第62回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"1046680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎, 友照"}],"nameIdentifiers":[{"nameIdentifier":"1046681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平石, 惇人"}],"nameIdentifiers":[{"nameIdentifier":"1046682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"1046683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"1046684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"1046685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塚越, 海渡"}],"nameIdentifiers":[{"nameIdentifier":"1046686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"1046687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"1046688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"1046689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomoteru, Yamasaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsuto, Hiraishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Fujinaga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanao, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaito, Tsukagoe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuki, Nengaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1046699","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"光感受性物質であるADPM06の18F標識合成及びインビボ評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"光感受性物質であるADPM06の18F標識合成及びインビボ評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-18"},"publish_date":"2022-05-18","publish_status":"0","recid":"86145","relation_version_is_last":true,"title":["光感受性物質であるADPM06の18F標識合成及びインビボ評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:13:51.021692+00:00"}