{"created":"2023-05-15T15:03:34.066583+00:00","id":86122,"links":{},"metadata":{"_buckets":{"deposit":"d093e803-4cf8-442a-b888-26ce494431de"},"_deposit":{"created_by":1,"id":"86122","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"86122"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00086122","sets":["1"]},"author_link":["1052388","1052397","1052398","1052393","1052396","1052395","1052399","1052394","1052390","1052387","1052386","1052389","1052391","1052400","1052401","1052392"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"1008","bibliographicVolumeNumber":"14 ","bibliographic_titles":[{"bibliographic_title":" Pharmaceutics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we evaluated the use of 15-(4-123I-iodophenyl)-3(R,S)-methylpentadecanoic acid (123I-BMIPP) to visualize fatty acid metabolism in bacteria for bacterial infection imaging. We found that 123I-BMIPP, which is used for fatty acid metabolism scintigraphy in Japan, accumulated markedly in Escherichia coli EC-14 similar to 18F-FDG, which has previously been studied for bacterial imaging. To elucidate the underlying mechanism, we evaluated changes in 123I-BMIPP accumulation under low-temperature conditions and in the presence of a CD36 inhibitor. The uptake of 123I-BMIPP by EC-14 was mediated via the CD36-like fatty-acid-transporting membrane protein and accumulated by fatty acid metabolism. In model mice infected with EC-14, the biological distribution and whole-body imaging were assessed using 123I-BMIPP and 18F-FDG. The 123I-BMIPP biodistribution study showed that, 8 h after infection, the ratio of 123I-BMIPP accumulated in infected muscle to that in control muscle was 1.31 at 60 min after 123I-BMIPP injection. In whole-body imaging 1.5 h after 123I-BMIPP administration and 9.5 h after infection, infected muscle exhibited a 1.33-times higher contrast than non-infected muscle. Thus, 123I-BMIPP shows potential for visualizing fatty acid metabolism of bacteria for imaging bacterial infections.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/pharmaceutics14051008","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1999-4923/14/5/1008/htm","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1999-4923","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muranaka , Yuka"}],"nameIdentifiers":[{"nameIdentifier":"1052386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizutani, Asuka"}],"nameIdentifiers":[{"nameIdentifier":"1052387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi , Masato"}],"nameIdentifiers":[{"nameIdentifier":"1052388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamoto , Koya"}],"nameIdentifiers":[{"nameIdentifier":"1052389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsue , Miki"}],"nameIdentifiers":[{"nameIdentifier":"1052390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takagi , Fumika"}],"nameIdentifiers":[{"nameIdentifier":"1052391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okazaki , Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"1052392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishi, Kodai"}],"nameIdentifiers":[{"nameIdentifier":"1052393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki , Kana"}],"nameIdentifiers":[{"nameIdentifier":"1052394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishii , Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"1052395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shikano , Naoto"}],"nameIdentifiers":[{"nameIdentifier":"1052396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto , Shigefumi"}],"nameIdentifiers":[{"nameIdentifier":"1052397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maki , Hideki"}],"nameIdentifiers":[{"nameIdentifier":"1052398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"1052399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kana, Yamazaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1052400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1052401","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"123I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"123I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"86122","relation_version_is_last":true,"title":["123I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:04:25.390139+00:00"}