{"created":"2023-05-15T15:03:33.752264+00:00","id":86115,"links":{},"metadata":{"_buckets":{"deposit":"14e8b0cd-f6dd-4902-82b8-669ebb14812b"},"_deposit":{"created_by":1,"id":"86115","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"86115"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00086115","sets":["1"]},"author_link":["1048844","1048835","1048834","1048845","1048832","1048833","1048836","1048843","1048846","1048831","1048841","1048829","1048839","1048840","1048842","1048837","1048838","1048830"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"5700","bibliographicPageStart":"5690","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Journal of Medicinal Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract:\nThis study aims to establish new labeling methods for no-carrier–added radio-Pt (191Pt) and to evaluate the in vitro properties of 191Pt-labeled agents compared with those of agents labeled with the common emitter 111In. 191Pt was complexed with the DNA-targeting dye Hoechst33258 via diethylenetriaminepentaacetic acid (DTPA) or the sulfur-containing amino acid cysteine (Cys). The intranuclear fractions of 191Pt- and 111In-labeled Hoechst33258 were comparable, indicating that the labeling for 191Pt via DTPA or Cys and the labeling for 111In via DTPA worked equally well. 191Pt showed a DNA-binding/cellular uptake ratio more than one order of magnitude greater than that of 111In. [191Pt]Pt-Hoechst33258 labeled via Cys showed a higher cellular uptake than that labeled via DTPA, resulting in a very high DNA-binding fraction of [191Pt]Pt-Cys-Hoechst33258 and extensive DNA damage. Our labeling methods of radio-Pt, especially via Cys, promote the development of radio-Pt-based agents for use in Auger electron therapy targeting DNA.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.jmedchem.1c02209","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02209","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-2623","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Honoka, Obata"}],"nameIdentifiers":[{"nameIdentifier":"1048829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsushi, Tsuji"}],"nameIdentifiers":[{"nameIdentifier":"1048830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsushi, Kumata"}],"nameIdentifiers":[{"nameIdentifier":"1048831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitomi, Sudo"}],"nameIdentifiers":[{"nameIdentifier":"1048832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsuyuki, Minegishi"}],"nameIdentifiers":[{"nameIdentifier":"1048833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu"}],"nameIdentifiers":[{"nameIdentifier":"1048834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideo, Takakura"}],"nameIdentifiers":[{"nameIdentifier":"1048835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mikako, Ogawa"}],"nameIdentifiers":[{"nameIdentifier":"1048836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akihiro, Kurimasa"}],"nameIdentifiers":[{"nameIdentifier":"1048837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1048838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honoka, Obata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsushi, Tsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsushi, Kumata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitomi, Sudo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsuyuki, Minegishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mikako, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1048846","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of novel 191Pt-labeled Hoechst33258: 191Pt is more suitable than 111In for targeting DNA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of novel 191Pt-labeled Hoechst33258: 191Pt is more suitable than 111In for targeting DNA"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-07"},"publish_date":"2022-04-07","publish_status":"0","recid":"86115","relation_version_is_last":true,"title":["Development of novel 191Pt-labeled Hoechst33258: 191Pt is more suitable than 111In for targeting DNA"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:10:49.078144+00:00"}