@article{oai:repo.qst.go.jp:00086036,
 author = {Arata, Oh-Nishi and Yuji, Nagai and Chie, Seki and Tetsuya, Suhara and Takafumi, Minamimoto and Makoto, Higuchi and Arata, Onishi and Yuji, Nagai and Chie, Seki and Tetsuya, Suhara and Takafumi, Minamimoto and Makoto, Higuchi},
 journal = {Brain, Behavior, & Immunity - Health},
 month = {Mar},
 note = {Maternal immune activation (MIA) is a risk factor for schizophrenia in the offspring. MIA in pregnant rodents can
be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (Poly I:C), which causes decreased
striatal dopamine D2 receptor (D2R) expression and behavioral dysfunction mediated by the dopaminergic system
in the offspring. However, previous studies did not determine whether Poly I:C induced cortical dopamine D2R
abnormality in an MIA rat model. In this study, we performed micro-positron emission tomography (micro-PET) in
vivo imaging and ex vivo neurochemical analyses of cortical D2Rs in MIA. In the micro-PET analyses, the anterior
cingulate cortex (ACC) region in the offspring showed significantly reduced binding potential for [11C]FLB457, a
high affinity radio-ligand toward D2Rs. Neurochemical analysis showed reduction of D2Rs and augmentation of
dopamine turnover in the ACC of the rat offspring. Thus, MIA induces dopaminergic dysfunction in the ACC of
offspring, similar to the neuronal pathology reported in patients with schizophrenia.},
 title = {Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model},
 volume = {22},
 year = {2022}
}