@misc{oai:repo.qst.go.jp:00086014,
 author = {Go, Akamatsu and Eiji, Yoshida and Hideaki, Tashima and Shigeki, Ito and Yuma, Iwao and Hidekatsu, Wakizaka and Miwako, Takahashi and Taiga, Yamaya and Go, Akamatsu and Eiji, Yoshida and Hideaki, Tashima and Shigeki, Ito and Yuma, Iwao and Hidekatsu, Wakizaka and Miwako, Takahashi and Taiga, Yamaya},
 month = {Apr},
 note = {[Purpose] The crosshair light sharing (CLS) PET detector, which has depth-of-interaction (DOI) capability, was recently developed by our group. In this work, as the first practical system based on the CLS detector, we developed a high-resolution portable small-animal PET with a long axial field-of-view (FOV) of 20 cm. 

[Methods] The system was composed of 128 CLS detectors*, which consisted of GFAG crystals and SiPMs. All devices were mounted on a compact pushcart (740 mm × 950 mm), and the system worked with a power supply from a typical wall socket of AC100V. The axial FOV was 207 mm, which covered a total-body of rat. Performance characterization was performed according to the NEMA NU4 standards. In addition, a 22Na ultra-micro hot phantom was used for spatial resolution measurement, and normal mouse and rat PET imaging with 18F-NaF and 18F-FDG was performed for imaging demonstration. 

[Results] The developed CLS-PET system successfully resolved 0.75 mm rods of the ultra-micro hot phantom. The sensitivity was 1.1% at the FOV center and the peak noise-equivalent count rate was 62 kcps@76 kBq/mL. The coincidence timing resolution was 496 ps. For the NaF-PET, mouse and rat total-body images were obtained, and detailed bone structures were clearly observed. For the mouse FDG-PET, cardiac FDG uptakes were clearly visualized. 

[Conclusion] The CLS-PET system achieved sub-mm spatial resolution and successfully provided mouse and rat total-body images. This portable small-animal PET system can offer opportunities for novel applications such as studies on PET-guided radiation therapy and PET-guided surgery.
*Yoshida, et al. Phys Med Biol. 2021;66:065013., 第123回日本医学物理学会学術大会},
 title = {CLS-PET: a high-resolution portable small-animal PET with a 20 cm axial FOV},
 year = {2022}
}