@misc{oai:repo.qst.go.jp:00085832,
 author = {Kiwamu, Matsuoka and Kiwamu, Matsuoka},
 month = {Mar},
 note = {Objectives: Although progressive supranuclear palsy (PSP) patients are known to exhibit apathy frequently, neuropathological processes leading to this phenotype remains elusive. The current study was aimed to examine the involvement of tau aggregations, oxidative stress (OS), and neuronal loss in the apathic manifestation of PSP patients.
Methods: Twenty PSP patients and 23 healthy controls (HCs) were enrolled. We evaluated tau depositions by PET with a specific probe, 18F-PM-PBB3, and brain volumes by MRI. Glutathione (GSH) levels as resilience measures against OS were also quantified by MRS in the anterior and posterior cingulate cortices (ACC and PCC).
Results: Tau pathologies were noted in the subcortical and cortical structures of the patient brains. Among these areas, tau accumulations were positively correlated with apathy scale (AS) in the angular gyrus (AG). Although PSP cases did not show alterations of GSH relative to HCs, GSH levels in PCC but not ACC were correlated with AS and tau depositions in AG. Marked atrophy was observed in the subcortical but not neocortical regions of PSP subjects, while gray matter (GM) volumes of the inferior frontal gyrus (IFG) and ACC were positively correlated with AS but had no relations to PET-detectable tau depositions and GSH. Finally, path analysis highlighted synergistic contributions of PET-detectable tau pathologies and GSH reductions in the posterior brain regions to AS, in parallel with associations of GM volume loss in the anterior brain regions with AS.
Conclusions: Our findings have indicated neural mechanisms underlying apathy in PSP may consist of PET-detectable tau aggregation and OS without marked neuronal loss in the posterior cortex and neuronal loss with neither PET-detectable tau pathologies nor OS in the anterior cortex., The 8th JHBI Talk Series},
 title = {Spatially distinct neural mechanisms differentially linking tau aggregations, oxidative stress, and neuronal loss to apathic phenotypes in progressive supranuclear palsy},
 year = {2022}
}