{"created":"2023-05-15T15:02:59.264659+00:00","id":85334,"links":{},"metadata":{"_buckets":{"deposit":"1c1c99b7-c78a-44c5-96d4-ed8698a8491c"},"_deposit":{"created_by":1,"id":"85334","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85334"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085334","sets":["2"]},"author_link":["1028528","1028518","1028517","1028520","1028525","1028519","1028521","1028526","1028515","1028529","1028523","1028522","1028527","1028516","1028524"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"181","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"Cancer Science "}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There are critical issues in siRNA therapeutics, as follows, 1) siRNA is immediately degraded in extracellular milieu, such as bloodstream, 2)\nthe size of siRNA is -5nm, so siRNA is readily excreted from the kidney to the urine, and 3) the negative charge of siRNA repels the negatively\ncharged cell membrane, inhibiting the cellular uptake of siRNA. Thus, many previous studies have encapsulated siRNA into -100 nm-sized\nnanoparticles to stabilize it. However, refractory cancers have tight barriers that prevent the penetration of such nanoparticles into cancer\ncells. To overcome these hurdles, a new type of siRNA nanocarrier is developed for the cancer-targeted siRNA delivery, using a Y-shaped\nblock catiomer (YBC) with precisely regulated chain length and precisely neutralize their charges. Indeed, two YBCs are bound to a single\nsiRNA in the bloodstream, generating a dynamic polyin-pair, termed uPIC. Owing to both high stability in the bloodstream and ultra-small\n(or optimal) size (-18 nm) to penetrate fibrotic tissues, uPIC efficiently delivers siRNA into murine models of fibrotic pancreatic cancer and\nglioblastoma, exerting the significant anticancer activity in vivo.","subitem_description_type":"Abstract"}]},"item_10003_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cas.14823","subitem_relation_type_select":"DOI"}}]},"item_10003_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/10.1111/cas.14823","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Sumiyo"}],"nameIdentifiers":[{"nameIdentifier":"1028515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Kotaro"}],"nameIdentifiers":[{"nameIdentifier":"1028516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tho, Kayoko"}],"nameIdentifiers":[{"nameIdentifier":"1028517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim, Hunjin"}],"nameIdentifiers":[{"nameIdentifier":"1028518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chaya, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"1028519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushima, Shigeto"}],"nameIdentifiers":[{"nameIdentifier":"1028520","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keisuke Katsushima"}],"nameIdentifiers":[{"nameIdentifier":"1028521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"1028522","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogura, Satomi"}],"nameIdentifiers":[{"nameIdentifier":"1028523","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cabral, Horacio"}],"nameIdentifiers":[{"nameIdentifier":"1028524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kensuke, Osada"}],"nameIdentifiers":[{"nameIdentifier":"1028525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiyama, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"1028526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyata, Kanjiro"}],"nameIdentifiers":[{"nameIdentifier":"1028527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"1028528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kensuke, Osada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1028529","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Unit polyion complex (uPIC) nanocarrier for siRNA delivery to glioblastoma and pancreatic cancer, Cancer Science ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Unit polyion complex (uPIC) nanocarrier for siRNA delivery to glioblastoma and pancreatic cancer, Cancer Science "}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-12"},"publish_date":"2022-01-12","publish_status":"0","recid":"85334","relation_version_is_last":true,"title":["Unit polyion complex (uPIC) nanocarrier for siRNA delivery to glioblastoma and pancreatic cancer, Cancer Science "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:52:36.175933+00:00"}