{"created":"2023-05-15T15:02:58.589671+00:00","id":85319,"links":{},"metadata":{"_buckets":{"deposit":"aa897382-2582-43b0-8944-b807277d8bf9"},"_deposit":{"created_by":1,"id":"85319","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85319"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085319","sets":["1"]},"author_link":["1041307","1041300","1041299","1041302","1041306","1041296","1041303","1041304","1041298","1041297","1041305","1041301"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"2467","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effectiveness of L- and D-amino acids for detecting the early stage of infection in bacterial imaging was compared. We evaluated the accumulation of 3H-L-methionine (Met), 3H-D-Met, 3H-L-alanine (Ala), and 3H-D-Ala in E. coli EC-14 and HaCaT cells. Biological distribution was assessed in control and lung-infection-model mice with EC-14 using 3H-L- and D-Met, and 18F-FDG. A maximum accumulation of 3H-L- and D-Met, and 3H-L- and D-Ala occurred in the growth phase of EC-14 in vitro. The accumulation of 3H-L-Met and L-Ala was greater than that of 3H-D-Met and D-Ala in both EC-14 and HaCaT cells. For all radiotracers, the accumulation was greater in EC-14 than in HaCaT cells at early time points. The accumulation was identified at 5 min after injection in EC-14, whereas the accumulation gradually increased in HaCaT cells over time. There was little difference in biodistribution between 3H-L-and D-Met except in the brain. 3H-L- and D-Met were sensitive for detecting areas of infection after the spread of bacteria throughout the body, whereas 18F-FDG mainly detected primary infection areas. Therefore, 11C-L- and D-Met, radioisotopes that differ only in terms of 3H labeling, could be superior to 18F-FDG for detecting bacterial infection in lung-infection-model mice.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35269610","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms23052467","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1422-0067/23/5/2467","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1422-0067","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muranaka, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"1041296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizutani, Asuka"}],"nameIdentifiers":[{"nameIdentifier":"1041297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamoto, Koya"}],"nameIdentifiers":[{"nameIdentifier":"1041298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsue, Miki"}],"nameIdentifiers":[{"nameIdentifier":"1041299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishi, Kodai"}],"nameIdentifiers":[{"nameIdentifier":"1041300","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Kana"}],"nameIdentifiers":[{"nameIdentifier":"1041301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii"}],"nameIdentifiers":[{"nameIdentifier":"1041302","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shikano, Naoto"}],"nameIdentifiers":[{"nameIdentifier":"1041303","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, Shigefumi"}],"nameIdentifiers":[{"nameIdentifier":"1041304","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"1041305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kana, Yamazaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041306","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041307","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of L- and D-Amino Acids for Bacterial Imaging in Lung Infection Mouse Model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of L- and D-Amino Acids for Bacterial Imaging in Lung Infection Mouse Model"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-25"},"publish_date":"2022-02-25","publish_status":"0","recid":"85319","relation_version_is_last":true,"title":["Comparison of L- and D-Amino Acids for Bacterial Imaging in Lung Infection Mouse Model"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:23:18.844356+00:00"}