{"created":"2023-05-15T15:02:56.228645+00:00","id":85267,"links":{},"metadata":{"_buckets":{"deposit":"2c0abbc3-55ae-40c0-8ea3-527157439b57"},"_deposit":{"created_by":1,"id":"85267","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85267"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085267","sets":["1"]},"author_link":["1045800","1045786","1045791","1045802","1045797","1045787","1045792","1045794","1045783","1045788","1045784","1045793","1045795","1045799","1045798","1045796","1045801","1045790","1045785","1045789"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"341","bibliographicPageStart":"334","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"ACS Omega"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD133 has been recognized as a prominent biomarker for cancer stem cells (CSCs), which promote tumor relapse and metastasis. Herein, we developed a clinically relevant, stable, peptide-based positron emission tomography (PET) tracer, [64Cu]CM-2, for mapping CD133 protein in several kinds of cancers. Through the incorporation of a 6-aminohexanoic acid (Ahx) into the N-terminus of a CM peptide, we constructed a stable peptide tracer [64Cu]CM-2, which exhibited specific binding to CD133-positive CSCs in multiple preclinical tumor models. Both PET imaging and ex vivo biodistribution verified the superb performance of [64Cu]CM-2. Furthermore, the matched physical- and biological half-life of [64Cu]CM-2 makes it a state-of-art PET tracer for CD133. Therefore, [64Cu]CM-2 PET may not only enable the longitudinal tracking of CD133 dynamics in the cancer stem cell niche, but also provide a powerful and noninvasive imaging tool to track down CSCs in refractory cancers.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acsomega.1c04711","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acsomega.1c04711","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2470-1343","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"1045783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ma, Xiaohui"}],"nameIdentifiers":[{"nameIdentifier":"1045784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie"}],"nameIdentifiers":[{"nameIdentifier":"1045785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"1045786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu"}],"nameIdentifiers":[{"nameIdentifier":"1045787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honoka, Obata"}],"nameIdentifiers":[{"nameIdentifier":"1045788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Lulu"}],"nameIdentifiers":[{"nameIdentifier":"1045789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu"}],"nameIdentifiers":[{"nameIdentifier":"1045790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Suzuki"}],"nameIdentifiers":[{"nameIdentifier":"1045791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shi, Rui"}],"nameIdentifiers":[{"nameIdentifier":"1045792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Weizhi"}],"nameIdentifiers":[{"nameIdentifier":"1045793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1045794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honoka, Obata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Suzuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1045802","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-13"},"publish_date":"2021-12-13","publish_status":"0","recid":"85267","relation_version_is_last":true,"title":["Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:15:13.452414+00:00"}