{"created":"2023-05-15T15:02:53.099733+00:00","id":85211,"links":{},"metadata":{"_buckets":{"deposit":"7f901824-e4b7-44c0-9c26-628506b76c36"},"_deposit":{"created_by":1,"id":"85211","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85211"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085211","sets":["10:28"]},"author_link":["1036092","1036094","1036090","1036095","1036091","1036093","1036096"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-10","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aggregation of the RNA-binding protein FUS (Fused in Sarcoma) has been implicated in the neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) [1]. The low-complexity domain of the FUS (FUS-LC) mediated liquid-liquid phase separation (LLPS) [2], but the structural mechanism is not known in detail. To address the revealing the mechanism, several structural analyses such as NMR or x-ray crystallography were examined [2, 3]. Reentry, Murakami and co-authors were performed Raman microscopy to analyze LLPS local structure [4]. They revealed that the FUS LC have extremely high concentrations which could not achieved in vitro experiments. In order to reveal the process to form LLPS such a high concentration, we examined the spectroscopic study using VUV-CD measurement, which can analyze the secondary structure of the proteins.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":" The 26th Hiroshima International Symposium on Synchrotron Radiation","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kentaro, Fujii"}],"nameIdentifiers":[{"nameIdentifier":"1036090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuo, Maita"}],"nameIdentifiers":[{"nameIdentifier":"1036091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masato, Kato"}],"nameIdentifiers":[{"nameIdentifier":"1036092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koichi, Matsuo(Hiroshima Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1036093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kentaro, Fujii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1036094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuo, Maita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1036095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masato, Kato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1036096","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Observation of Liquid-Liquid Phase Separation of  FUS-LC using VUV-CD Spectroscopy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Observation of Liquid-Liquid Phase Separation of  FUS-LC using VUV-CD Spectroscopy"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-14"},"publish_date":"2022-03-14","publish_status":"0","recid":"85211","relation_version_is_last":true,"title":["Observation of Liquid-Liquid Phase Separation of  FUS-LC using VUV-CD Spectroscopy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:32:15.408541+00:00"}