{"created":"2023-05-15T15:02:51.969674+00:00","id":85194,"links":{},"metadata":{"_buckets":{"deposit":"01e653cd-6d5f-4ecb-828e-5f56324ee4a8"},"_deposit":{"created_by":1,"id":"85194","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85194"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085194","sets":["1"]},"author_link":["1027026","1027019","1027022","1027030","1027031","1027021","1027034","1027024","1027035","1027029","1027033","1027036","1027028","1027027","1027018","1027023","1027025","1027032","1027020"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1772","bibliographicPageStart":"1763","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Bioconjugate Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Targeted radionuclide therapy (TRT) provides new and safe opportunities for cancer treatment and management with high precision and efficiency. Here we have designed a novel semiconducting polymer nanoparticle (SPN)-based\nradiopharmaceutical (211At-MeATE-SPN-GIP) for TRT against glucose-dependent insulinotropic polypeptide receptor (GIPR)-positive cancers to further explore the applications of nano-engineered TRT. 211At-MeATE-SPN-GIP was engineered\nvia nanoprecipitation, followed by its functionalization with a glucose-dependent insulinotropic polypeptide (GIP) to target\nGIPR and deliver 211At for α therapy. The therapeutic effect and biological safety of 211At-MeATE-SPN-GIP were investigated using GIPR-overexpressing human pancreatic cancer CFPAC-1 cells and CFPAC-1-bearing mice. In this work, 211At-MeATE-SPN-GIP was produced with a radiochemical yield of 43% and radiochemical purity of 98%, which exhibited a specifically high uptake in CFPAC-1 cells, inducing cell cycle arrest at G2/M phase and extensive DNA damage. In the\nCFPAC-1-bearing tumor model, 211At-MeATE-SPN-GIP exhibited high therapeutic efficiency, with no obvious side effects. The GIPR-specific binding of 211At-MeATE-SPN-GIP combined with effective inhibition of tumor growth, and fewer side effects compared to control suggest that 211At-MeATE-SPN-GIP TRT holds great potential as a novel nano-engineered TRT strategy for patients with GIPR-positive cancer.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.bioconjchem.1c00263","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00263","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1043-1802","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shi, Xiumin"}],"nameIdentifiers":[{"nameIdentifier":"1027018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Qing, Li"}],"nameIdentifiers":[{"nameIdentifier":"1027019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lulu, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"1027020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu"}],"nameIdentifiers":[{"nameIdentifier":"1027021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie"}],"nameIdentifiers":[{"nameIdentifier":"1027022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"1027023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu"}],"nameIdentifiers":[{"nameIdentifier":"1027024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chuan, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"1027025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhengcan, Wu"}],"nameIdentifiers":[{"nameIdentifier":"1027026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WANG, Feng"}],"nameIdentifiers":[{"nameIdentifier":"1027027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1027028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kai, Yang"}],"nameIdentifiers":[{"nameIdentifier":"1027029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ran, Zhu"}],"nameIdentifiers":[{"nameIdentifier":"1027030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1027031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1027032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1027033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1027034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WANG, Feng","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1027035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1027036","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"211At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"211At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-01"},"publish_date":"2021-07-01","publish_status":"0","recid":"85194","relation_version_is_last":true,"title":["211At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:56:54.304170+00:00"}