{"created":"2023-05-15T15:02:51.567465+00:00","id":85188,"links":{},"metadata":{"_buckets":{"deposit":"17c723c1-0290-440a-a42b-87c7f561f45c"},"_deposit":{"created_by":1,"id":"85188","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85188"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085188","sets":["1"]},"author_link":["1042550","1042538","1042530","1042549","1042539","1042544","1042546","1042537","1042531","1042533","1042542","1042548","1042536","1042543","1042534","1042551","1042547","1042540","1042545","1042535","1042532","1042541"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1376","bibliographicPageStart":"1363","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Acta Pharmaceutica Sinica B"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract Peptides that are composed of dextrorotary (D)-amino acids have gained increasing\nattention as a potential therapeutic class. However, our understanding of the in vivo fate of D-peptides\nis limited. This highlights the need for whole-body, quantitative tracking of D-peptides to better\nunderstand how they interact with the living body. Here, we used mouse models to track the\nmovement of a programmed death-ligand 1 (PD-L1)-targeting D-dodecapeptide antagonist (DPA)\nusing positron emission tomography (PET). More specifically, we profiled the metabolic routes of\n[\n64Cu]DPA and investigated the tumor engagement of [\n64Cu/68Ga]DPA in mouse models. Our results\nrevealed that intact [\n64Cu/68Ga]DPA was primarily eliminated by the kidneys and had a notable\naccumulation in tumors. Moreover, a single dose of [\n64Cu]DPA effectively delayed tumor growth\nand improved the survival of mice. Collectively, these results not only deepen our knowledge of the\nin vivo fate of D-peptides, but also underscore the utility of D-peptides as radiopharmaceuticals.\nKEY WORDS D-peptide; PET imaging; Radiotheranostics; In vivo fate; PD-L1\nAbbreviations: 2D, two-dimensional; 3D, three-dimensional; CPM, radioactivity per minute; DAB,\n3,3-diaminobenzidine; DMEM, Dulbecco’s modified Eagle medium; DMSO, dimethyl sulfoxide;\nDMF, dimethylformamide; DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; DPA,\nD-dodecapeptide antagonist; FBS, fetal bovine serum; FITC, fluorescein isothiocyanate; HCT,\nhematocrit; H&E, Hematoxylin and Eosin; HPLC, high performance liquid chromatography; mAb,\nmonoclonal antibody; MD, molecular dynamics; MIP, maximum intensity projection; MIPD,\nmirror-image phage display; PCNA, proliferating cell nuclear antigen; PD-L1, programmed deathligand 1; PET, positron emission tomography; PLC, platelet; RBC, red blood cells; TAC, time‒\nactivity curves; TFA, trifluoroacetic acid; TLC, thin layer chromatography; TRT, targeted\nradionuclide therapy; WBC, white blood cell.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Chinese Academy of Medical Sciences"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.apsb.2021.09.016","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2211383521003580?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2211-3835","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"1042530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wu, Wenyu"}],"nameIdentifiers":[{"nameIdentifier":"1042531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie"}],"nameIdentifiers":[{"nameIdentifier":"1042532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Geng, Hao"}],"nameIdentifiers":[{"nameIdentifier":"1042533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"1042534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu"}],"nameIdentifiers":[{"nameIdentifier":"1042535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Lulu"}],"nameIdentifiers":[{"nameIdentifier":"1042536","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Yinghuan"}],"nameIdentifiers":[{"nameIdentifier":"1042537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu"}],"nameIdentifiers":[{"nameIdentifier":"1042538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Suzuki"}],"nameIdentifiers":[{"nameIdentifier":"1042539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Guo, Jialin"}],"nameIdentifiers":[{"nameIdentifier":"1042540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wu, Yundong"}],"nameIdentifiers":[{"nameIdentifier":"1042541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Zigang"}],"nameIdentifiers":[{"nameIdentifier":"1042542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Feng"}],"nameIdentifiers":[{"nameIdentifier":"1042543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1042544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Suzuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042551","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-08"},"publish_date":"2021-10-08","publish_status":"0","recid":"85188","relation_version_is_last":true,"title":["Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:21:36.493972+00:00"}