{"created":"2023-05-15T15:02:43.328619+00:00","id":85039,"links":{},"metadata":{"_buckets":{"deposit":"3c591006-9732-4edd-b3fb-16e591ea26b2"},"_deposit":{"created_by":1,"id":"85039","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85039"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085039","sets":["1"]},"author_link":["1025530","1025527","1025533","1025535","1025534","1025529","1025531","1025536","1025532","1025526","1025528"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"61","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Pharmaceutics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Gastrointestinal tract absorption of cationic anticancer drugs and medicines was estimated using whole-body imaging following oral [123I]MIBG administration. [123I]MIBG was added to cultures of human embryonic kidney (HEK)293 cells expressing human organic anion transporting polypeptide (OATP)2B1, carnitine/organic cation transporter (OCTN)1 and OCTN2, and organic cation transporter (OCT)1, OCT2, and OCT3 with and without cimetidine (an OCTN and OCT inhibitor) and L-carnitine (an OCTN inhibitor). Biodistribution analyses and single-photon emission computed tomography (SPECT) imaging in normal and dextran sodium sulfate (DSS)-induced experimental colitis mice were conducted using [123I]MIBG with and without cimetidine. [123I]MIBG uptake was significantly higher in HEK293/OCTN1, 2, and OCT1-3 cells than in mock cells. Uptake via OCTN was inhibited by L-carnitine, whereas OCT-mediated uptake was inhibited by cimetidine. Biodistribution analyses and SPECT imaging studies showed significantly lower accumulation of [123I]MIBG in the blood, heart, liver, and bladder in DSS-induced experimental colitis mice and mice with cimetidine loading compared with normal mice, whereas significantly higher accumulation in the stomach and kidney was observed after [123I]MIBG injection. [123I]MIBG imaging after oral administration can be used to estimate gastrointestinal absorption in the small intestine via OCTN and/or OCT by measuring radioactivity in the heart, liver, and bladder.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/pharmaceutics14010061","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1999-4923/14/1/61","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1999-4923","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Masato"}],"nameIdentifiers":[{"nameIdentifier":"1025526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizutani , Asuka"}],"nameIdentifiers":[{"nameIdentifier":"1025527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Muranaka , Yuka"}],"nameIdentifiers":[{"nameIdentifier":"1025528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishi , Kodai"}],"nameIdentifiers":[{"nameIdentifier":"1025529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komori , Hisakazu"}],"nameIdentifiers":[{"nameIdentifier":"1025530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii"}],"nameIdentifiers":[{"nameIdentifier":"1025531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shikano , Naoto"}],"nameIdentifiers":[{"nameIdentifier":"1025532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi , Takeo"}],"nameIdentifiers":[{"nameIdentifier":"1025533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamai , Ikumi"}],"nameIdentifiers":[{"nameIdentifier":"1025534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai , Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"1025535","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1025536","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Biological Distribution of Orally Administered [123I]MIBG for Estimating Gastrointestinal Tract Absorption","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biological Distribution of Orally Administered [123I]MIBG for Estimating Gastrointestinal Tract Absorption"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-14"},"publish_date":"2022-01-14","publish_status":"0","recid":"85039","relation_version_is_last":true,"title":["Biological Distribution of Orally Administered [123I]MIBG for Estimating Gastrointestinal Tract Absorption"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:02:35.576119+00:00"}