@article{oai:repo.qst.go.jp:00085017,
 author = {上野, 恵美 and 中西, 郁夫 and 松本, 謙一郎 and Megumi, Ueno and Ikuo, Nakanishi and Kenichiro, Matsumoto},
 journal = {2020年度量子医科学研究所重粒子線がん治療装置等共同利用研究報告書​},
 month = {Nov},
 note = {Density of hydroxyl radical (•OH) and hydrogen peroxide (H2O2) generated in water irradiated by carbon-ion beam was estimated under aerobic and hypoxic conditions. TBARS induced in an oil or liposome suspension samples were measured.
For •OH detection, a concentration series of DMPO water solutions (0.49‒2278 mM) were irradiated by 32 Gy carbon-ion beam. For detection of H2O2 cluster, a concentration series of TEMPOL water solutions (0.76‒1661 μM) were irradiated 0.5‒256 Gy carbonion beam according to the concentration of TEMPOL. For TBARS estimation, oil or liposome suspension samples were irradiated 256 Gy.
Intermolecular distance of sparse •OH induced by X-ray was estimated as 7.1 and 8.8 nm under aerobic and hypoxic condition, and that by 80 keV/μm carbon-ion beam was 6.3 and 7.9 nm under aerobic and hypoxic condition, respectively. Intermolecular distance of dense •OH may be different between aerobic and hypoxic condition, but details could not be evaluated from this experiment. Internal distance between H2O2 clusters was estimated as 59.0, 17.7 and 19.5 nm induced by X-ray, and 20 and 80 keV/μm carbon-ion beam under aerobic condition, respectively. However, those were estimated as 80.4, 108.9 and 97.9 nm under hypoxic condition for X-ray, and 20 and 80 keV/μm carbon-ion beam, respectively. No increase of TBARS was observed in oil or lipid membrane after 256 Gy irradiation of X-ray, and 20 and 80 keV/μm carbon-ion beam.},
 pages = {158--159},
 title = {炭素線が水溶液試料、O/W エマルジョン試料、あるいはリポソーム懸濁液試料中に生成する活 性酸素種の定量とそれによって生じる酸化反応量の評価},
 year = {2021}
}