@article{oai:repo.qst.go.jp:00084998,
 author = {Miwako, Takahashi and Yoshimura, Shuntaro and Sodai, Takyu and Aikou, Susumu and Okumura, Yasuhiro and Yagi, Koichi and Fukayama, Masashi and Momose, Toshimitsu and Seto, Yasuyuki and Taiga, Yamaya and Miwako, Takahashi and Sodai, Takyu and Seto, Yasuyuki and Taiga, Yamaya},
 journal = {Annals of Nuclear Medicine},
 month = {Nov},
 note = {Purpose
To reduce postoperative complications, intraoperative lymph node (LN) diagnosis with 18F-fluoro-2-deoxy-D-glucose (FDG) is expected to optimize the extent of LN dissection, leading to less invasive surgery. However, such a diagnostic device has not yet been realized. We proposed the concept of coincidence detection wherein a pair of scintillation crystals formed the head of the forceps. To estimate the clinical impact of this detector, we determined the cut-off value using FDG as a marker for intraoperative LN diagnosis in patients with esophageal cancer, the specifications needed for the detector, and its feasibility using numerical simulation.

Methods
We investigated the dataset including pathological diagnosis and radioactivity of 1073 LNs resected from 20 patients who underwent FDG-positron emission tomography followed by surgery for esophageal cancer on the same day. The specifications for the detector were determined assuming that it should measure 100 counts (less than 10% statistical error) or more within the intraoperative measurement time of 30 s. The detector sensitivity was estimated using GEANT4 simulation and the expected diagnostic ability was calculated.

Results
The cut-off value was 620 Bq for intraoperative LN diagnosis. The simulation study showed that the detector had a radiation detection sensitivity of 0.96%, which was better than the estimated specification needed for the detector. Among the 1035 non-metastatic LNs, 815 were below the cut-off value.

Conclusion
The forceps-type coincidence detector can provide sufficient sensitivity for intraoperative LN diagnosis. Approximately 80% of the prophylactic LN dissections in esophageal cancer can be avoided using this detector.},
 pages = {285--292},
 title = {A design of forceps-type coincidence radiation detector for intraoperative LN diagnosis: clinical impact estimated from LNs data of 20 esophageal cancer patients},
 volume = {36},
 year = {2021}
}