{"created":"2023-05-15T15:02:33.944846+00:00","id":84833,"links":{},"metadata":{"_buckets":{"deposit":"be616aee-b784-448c-8cae-4aba5c081ac2"},"_deposit":{"created_by":1,"id":"84833","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84833"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084833","sets":["1"]},"author_link":["1050580","1050576","1050584","1050575","1050585","1050583","1050578","1050582","1050579","1050577","1050581"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"109","bibliographicPageStart":"101","bibliographicVolumeNumber":"239","bibliographic_titles":[{"bibliographic_title":"The Journal of pediatrics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To determine the optimal quantitative magnetic resonance (MR) biomarker in neonatal encephalopathy following therapeutic hypothermia based on scan timing.\n\nStudy design: This retrospective study included 98 neonates (35-41 weeks of gestation) with neonatal encephalopathy, who underwent therapeutic hypothermia; diffusion-weighted imaging and proton MR spectroscopy were performed at 24-96 hours (n = 56) and 7-14 days (n = 92) after birth, respectively, to estimate apparent diffusion coefficient (ADC) values, N-acetylaspartate and N-acetylaspartylglutamate (tNAA), lactate, and choline concentrations, and lactate/tNAA, tNAA/choline ratios in the deep gray matter. Adverse outcomes included death or neurodevelopmental impairment at 18-22 months of age. We used receiver operating characteristic curves to examine the prognostic accuracy of each MR biomarker.\n\nResults: Deep gray matter tNAA concentrations showed the best prognostic value, with an area under the curve (AUC) of 0.97 and 1.00 at 24-96 hours and 7-14 days after birth, respectively. At 24-96 hours of age, ADC values, lactate concentrations, and lactate/tNAA ratios showed prognostic value with AUCs of 0.90, 0.95, and 0.97, respectively. At 7-14 days of age, the AUCs of ADC values, lactate, and lactate/tNAA ratios were 0.61, 0.67, and 0.80, respectively; these were lower than those at 24-96 hours of age.\n\nConclusions: During the first 2 weeks of life, the deep gray matter tNAA concentration was the most accurate quantitative MR biomarker. Although ADC values, lactate levels, and lactate/tNAA ratios also showed high prognostic value during 24-96 hours of life, only tNAA retained high prognostic value in the second week of life.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34391766","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jpeds.2021.08.011","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/abs/pii/S0022347621007678?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-3476","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibasaki, Jun"}],"nameIdentifiers":[{"nameIdentifier":"1050575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Tetsu"}],"nameIdentifiers":[{"nameIdentifier":"1050576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aurélie, Piedvache"}],"nameIdentifiers":[{"nameIdentifier":"1050577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomiyasu, Moyoko"}],"nameIdentifiers":[{"nameIdentifier":"1050578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morisaki, Naho"}],"nameIdentifiers":[{"nameIdentifier":"1050579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujii, Yuta"}],"nameIdentifiers":[{"nameIdentifier":"1050580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyoshima, Katsuaki"}],"nameIdentifiers":[{"nameIdentifier":"1050581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aida, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"1050582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsu, Niwa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moyoko, Tomiyasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriko, Aida","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1050585","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of Predictive Values of Magnetic Resonance Biomarkers Based on Scan Timing in Neonatal Encephalopathy Following Therapeutic Hypothermia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of Predictive Values of Magnetic Resonance Biomarkers Based on Scan Timing in Neonatal Encephalopathy Following Therapeutic Hypothermia"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-15"},"publish_date":"2021-09-15","publish_status":"0","recid":"84833","relation_version_is_last":true,"title":["Comparison of Predictive Values of Magnetic Resonance Biomarkers Based on Scan Timing in Neonatal Encephalopathy Following Therapeutic Hypothermia"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:07:47.667242+00:00"}