{"created":"2023-05-15T15:02:26.310956+00:00","id":84662,"links":{},"metadata":{"_buckets":{"deposit":"639ca59d-bf76-4144-b44e-777c78d6a318"},"_deposit":{"created_by":1,"id":"84662","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84662"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084662","sets":["1"]},"author_link":["1021815","1021814","1021813","1021812","1021811","1021810"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"101302","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Applied Materials Today"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ガリウムベースの液体金属（LM）ナノ粒子は、その独特の特性からさまざまな研究分野に応用されてきた。 LMナノ粒子の表面修飾の設計は、物理化学的多機能化に加えて、LMの本来の特性を強化するために必要不可欠である。本研究では、超音波処理法とγ線照射法を組み合わせることにより、ガリウム-インジウム結晶と、ゼラチン、デオキシリボ核酸、レシチン、ウシ血清アルブミンなどのさまざまな生体分子をベースにしたコアシェルタイプのナノ粒子を開発した。特に、ゼラチンを修飾したLMナノ粒子は、優れた水分散性、独特の形態、均一な粒子サイズ、低毒性、特徴的な吸光度、強力な光熱変換、高い細胞内浸透能力、強力な光熱抗癌効果、および蛍光プローブによる機能化特性を示した。この機能性を有するLMナノ粒子はその透過性と保持効果により、標的腫瘍位置の蛍光による診断を可能とした。さらに、LMナノ粒子を取り込ませたマウスに生物学的に透過可能な近赤外レーザーを照射することで、標的腫瘍切除を引き起こすことに成功した。本研究は、癌治療におけるオプトセラノスティックスを進歩させるためのLMプラットフォームを提供する。","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.apmt.2021.101302","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/abs/pii/S2352940721003656","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2352-9407","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yun, Qi"}],"nameIdentifiers":[{"nameIdentifier":"1021810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsushi, Kimura"}],"nameIdentifiers":[{"nameIdentifier":"1021811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsumasa, Taguchi"}],"nameIdentifiers":[{"nameIdentifier":"1021812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyako, Eijiro"}],"nameIdentifiers":[{"nameIdentifier":"1021813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsushi, Kimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsumasa, Taguchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021815","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sonication - and γ-ray-mediated biomolecule-liquid metal nanoparticlization in cancer optotheranostics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sonication - and γ-ray-mediated biomolecule-liquid metal nanoparticlization in cancer optotheranostics"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-02"},"publish_date":"2021-12-02","publish_status":"0","recid":"84662","relation_version_is_last":true,"title":["Sonication - and γ-ray-mediated biomolecule-liquid metal nanoparticlization in cancer optotheranostics"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:16:52.949755+00:00"}