{"created":"2023-05-15T15:02:26.265957+00:00","id":84661,"links":{},"metadata":{"_buckets":{"deposit":"e68f1053-b352-4ea1-9746-a9cfd9e756f0"},"_deposit":{"created_by":1,"id":"84661","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84661"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084661","sets":["1"]},"author_link":["1021807","1021808","1021809","1021806"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"118","bibliographicPageStart":"111","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Current Opinion in Genetics & Development"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Eukaryotic cells express thousands of protein domains long believed to function in the absence of molecular order. These intrinsically disordered protein (IDP) domains are typified by gibberish-like repeats of only a limited number of amino acids that we refer to as domains of low sequence complexity. A decade ago, it was observed that these low complexity (LC) domains can undergo phase transition out of aqueous solution to form either liquid-like droplets or hydrogels. The self-associative interactions responsible for phase transition involve the formation of specific cross-β structures that are unusual in being labile to dissociation. Here we give evidence that the LC domains of two RNA binding proteins, ataxin-2 and TDP43, form cross-β interactions that specify biologically relevant redox sensors.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.gde.2020.12.006","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/abs/pii/S0959437X20301702?via%3Dihub#!","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0959-437X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Masato, Kato"}],"nameIdentifiers":[{"nameIdentifier":"1021806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"P Tu, Benjamin"}],"nameIdentifiers":[{"nameIdentifier":"1021807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"L McKnight, Steven"}],"nameIdentifiers":[{"nameIdentifier":"1021808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masato, Kato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021809","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Redox-mediated regulation of low complexity domain self-association","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Redox-mediated regulation of low complexity domain self-association"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-12"},"publish_date":"2021-11-12","publish_status":"0","recid":"84661","relation_version_is_last":true,"title":["Redox-mediated regulation of low complexity domain self-association"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:16:52.581742+00:00"}