{"created":"2023-05-15T15:02:25.816526+00:00","id":84651,"links":{},"metadata":{"_buckets":{"deposit":"f7549bde-ac1e-4397-9af4-df5f9cfe75dc"},"_deposit":{"created_by":1,"id":"84651","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84651"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084651","sets":["1"]},"author_link":["1021652","1021673","1021658","1021667","1021670","1021671","1021644","1021648","1021664","1021654","1021641","1021675","1021657","1021651","1021646","1021663","1021650","1021674","1021647","1021665","1021662","1021660","1021672","1021661","1021659","1021668","1021640","1021643","1021642","1021676","1021645","1021656","1021669","1021666","1021649","1021653","1021655"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"212","bibliographicPageStart":"197","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Journal of Cerebral Blood Flow & Metabolism"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To assess if magnetic resonance spectroscopy (MRS)-measured Glutamate (Glu) and GABA reflect excitatory and inhibitory neural activities, respectively, we conducted MRS measurements along with two-photon mesoscopic imaging\nof calcium signals in excitatory and inhibitory neurons of living, unanesthetized mice. For monitoring stimulus-driven activations of a brain region, MRS signals and mesoscopic neural activities were measured during two consecutive\nsessions of 15-min prolonged sensory stimulations. In the first session, putative excitatory neuronal activities were increased, while inhibitory neuronal activities remained at the baseline level. In the second half, while excitatory neuronal activities remained elevated, inhibitory neuronal activities were significantly enhanced. We assessed regional\nneurochemical statuses by measuring MRS signals, which were overall in accordance with the neural activities, and neuronal activities and neurochemical statuses in a mouse model of Dravet syndrome under resting condition.\nMesoscopic assessments showed that activities of inhibitory neurons in the cortex were diminished relative to wildtype mice in contrast to spared activities of excitatory neurons. Consistent with these observations, the Dravet model\nexhibited lower concentrations of GABA than wild-type controls. Collectively, the current investigations demonstrate that MRS-measured Glu and GABA can reflect spontaneous and stimulated activities of neurons producing and releasing\nthese neurotransmitters in an awake condition.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SAGE"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34515548","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1177/0271678X211045449","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://journals.sagepub.com/doi/full/10.1177/0271678X211045449","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0271-678X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata 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Shimojo"}],"nameIdentifiers":[{"nameIdentifier":"1021645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoko, Uchida"}],"nameIdentifiers":[{"nameIdentifier":"1021646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuhiro, Nitta"}],"nameIdentifiers":[{"nameIdentifier":"1021647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sayaka, Shibata"}],"nameIdentifiers":[{"nameIdentifier":"1021648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keisuke, Nagashima"}],"nameIdentifiers":[{"nameIdentifier":"1021649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshihiro, Ochi"}],"nameIdentifiers":[{"nameIdentifier":"1021650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maiko, Ono"}],"nameIdentifiers":[{"nameIdentifier":"1021651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jun, Maeda"}],"nameIdentifiers":[{"nameIdentifier":"1021652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yutaka, Tomita"}],"nameIdentifiers":[{"nameIdentifier":"1021653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruhiko, Sahara"}],"nameIdentifiers":[{"nameIdentifier":"1021654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Near, Jamie"}],"nameIdentifiers":[{"nameIdentifier":"1021655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki"}],"nameIdentifiers":[{"nameIdentifier":"1021656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhisa, Shibata"}],"nameIdentifiers":[{"nameIdentifier":"1021657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi"}],"nameIdentifiers":[{"nameIdentifier":"1021658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuhei, Takado","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroyuki, Takuwa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sampei, Kazuaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuya, Urushihata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Manami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masafumi, Shimojo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoko, Uchida","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021665","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuhiro, Nitta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021666","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sayaka, Shibata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021667","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keisuke, Nagashima","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshihiro, Ochi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maiko, Ono","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021670","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jun, Maeda","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yutaka, Tomita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruhiko, Sahara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhisa, Shibata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021676","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-13"},"publish_date":"2021-11-13","publish_status":"0","recid":"84651","relation_version_is_last":true,"title":["MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:17:14.585577+00:00"}