{"created":"2023-05-15T15:02:21.692571+00:00","id":84559,"links":{},"metadata":{"_buckets":{"deposit":"e07e663c-89e8-40b6-91a5-3c89313c384d"},"_deposit":{"created_by":1,"id":"84559","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84559"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084559","sets":["1"]},"author_link":["1020516","1020517","1020521","1020514","1020527","1020531","1020533","1020526","1020524","1020513","1020528","1020532","1020520","1020515","1020522","1020525","1020529","1020530","1020518","1020519","1020523"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"21","bibliographicPageEnd":"15857","bibliographicPageStart":"15846","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Journal of Medicinal Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The high in vivo stability of 2,2-dihydroxymethyl-3-[18F]fluoropropyl-2-nitroimidazole ([18F]DiFA) prompted us to evaluate neopentyl as a scaffold to prepare a radiotheranostic system with radioiodine and astatine.Three DiFA derivatives with one, two, or without a hydroxyl group were synthesized. While all 125I-labeled compounds remained stable against nucleophilic substitution, only a 125I-labeled neopentyl glycol was stable against cytochrome P450 (CYP)-mediated metabolism and showed high stability against in vivo deiodination. 211At-labeled neopentyl glycol also remained stable against both nucleophilic substitution and CYP-mediated metabolism. 211At labeled neopentyl glycol showed the biodistribution profiles similar to those of its radioiodinated counterpart in contrast to the 125I/211At-labeled benzoate pair. The urine analyses confirmed that 211At-labeled neopentyl glycol was excreted in the urine as a glucuronide conjugate with the absence of free [211At]At-. These findings indicate that neopentyl glycol would constitute a promising scaffold to prepare a radiotheranostic system with radioiodine and 211At.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.jmedchem.1c01147","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01147","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-2623","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Hiroyuki (Chiba Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaizuka,, Yuta (Chiba Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuta,, Maho (Tokyo Inst. Tech.)"}],"nameIdentifiers":[{"nameIdentifier":"1020515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroshi (Tokyo Inst. Tech.)"}],"nameIdentifiers":[{"nameIdentifier":"1020516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Washiya,, Nana (Chiba Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shirakami,, Yoshifumi (Osaka Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ooe,, Kazuhiro (Osaka Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyoshima,, Atsushi (Osaka Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020520","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watabe,, Tadashi (Osaka Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Teramoto,, Takahiro (Osaka Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020522","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichiro, Sasaki"}],"nameIdentifiers":[{"nameIdentifier":"1020523","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeki, Watanabe"}],"nameIdentifiers":[{"nameIdentifier":"1020524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriko, Ishioka"}],"nameIdentifiers":[{"nameIdentifier":"1020525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatazawa,, Jun (Osaka Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uehara,, Tomoya (Chiba Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arano,, Yasushi (Chiba Univ.)"}],"nameIdentifiers":[{"nameIdentifier":"1020528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroyuki, Suzuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Tanaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichiro, Sasaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeki, Watanabe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriko, Ishioka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020533","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neopentyl glycol as a scaffold to provide radiohalogenated theranostic pairs of high in vivo stability","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neopentyl glycol as a scaffold to provide radiohalogenated theranostic pairs of high in vivo stability"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-08-25"},"publish_date":"2021-08-25","publish_status":"0","recid":"84559","relation_version_is_last":true,"title":["Neopentyl glycol as a scaffold to provide radiohalogenated theranostic pairs of high in vivo stability"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:20:47.885039+00:00"}