{"created":"2023-05-15T15:02:19.411594+00:00","id":84509,"links":{},"metadata":{"_buckets":{"deposit":"e780e4ce-c8ea-4fce-a3ef-11949735a9ca"},"_deposit":{"created_by":1,"id":"84509","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84509"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084509","sets":["10:28"]},"author_link":["1020115","1020113","1020118","1020111","1020120","1020114","1020112","1020116","1020117","1020110","1020119","1020121"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"全-trans-レチノイン酸（ATRA）およびその人工類縁体は核内受容体の活性化を通して抗がん作用を示すが，近年，中枢神経系変性疾患に対する改善効果にも大きな注目が集まり，国内外でレチノイド類のPET脳イメージングが試みられている。本研究は，脳疾患に関係する最適治療薬の開発に直結する高い脳移行性を有するPETプローブの開発を目的とした。ATRAの化学的および代謝不安定性を鑑み，より安定な非環式レチノイド（ぺレチノイン）に着目し，パラジウム錯体を介する高速カップリング反応による高効率な11C標識化によりPETトレーサーの安定供給を可能にした。続いて，ラットおよびサルを用いた脳PET研究により11C標識ペレチノインの高い脳移行性を観測した。これらの成果は，これまでのレチノイド類のがん研究に加えて新たに脳研究分野を加え，レチノイド類の疾患診断薬や治療薬の開発を助長する重要な知見である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第61回　日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"1020110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koyama, Hiroko"}],"nameIdentifiers":[{"nameIdentifier":"1020111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"1020112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogata, Aya"}],"nameIdentifiers":[{"nameIdentifier":"1020113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideki Ishii"}],"nameIdentifiers":[{"nameIdentifier":"1020114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"1020115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"1020116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"1020117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"1020118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kengo Ito"}],"nameIdentifiers":[{"nameIdentifier":"1020119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideki, Ishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020121","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Synthesis of 11C-labeled acyclic retinoid,[11C]peretinoin, with high brain permeability","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of 11C-labeled acyclic retinoid,[11C]peretinoin, with high brain permeability"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-11"},"publish_date":"2022-01-11","publish_status":"0","recid":"84509","relation_version_is_last":true,"title":["Synthesis of 11C-labeled acyclic retinoid,[11C]peretinoin, with high brain permeability"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:22:50.624898+00:00"}