{"created":"2023-05-15T15:02:18.839811+00:00","id":84496,"links":{},"metadata":{"_buckets":{"deposit":"63970825-b155-4d6c-a3ff-c7812f545737"},"_deposit":{"created_by":1,"id":"84496","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84496"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084496","sets":["10:28"]},"author_link":["1019991","1019992","1019993","1019987","1019990","1019986","1019989","1019988"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-12-19","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose\nWe excelled off-target binding using computer chemistry techniques and worked on the development of PET imaging agents that bind to glutamate transporter (GLT). Although a plurality of asymmetric carbons generated within the compound skeleton could be excluded by structure optimization, there was a problem with deprotection of the aspartic acid skeleton in the skeleton. This study aims at establishing synthesis reactions that do not require protection / deprotection reaction by Click-Reaction, recalculation of In Silico binding assay, and synthesis of obtained structural compounds.\nMethod\nIn silico binding assay we derive the predominant and ERα non-binding structure in GLT binding and have studied labeling by [18F] on synthesis and synthesizer.  In the structure reported earlier, there was a problem in deprotection of the aspartic acid skeleton in the skeleton. We examined the establishment of synthetic reactions that do not require protection / deprotection reaction by Click-Reaction.\nResults and discussion\nWe have established a design and synthesis route for compounds excluding asymmetric positions. However, as the yield in the deprotection reaction was low, a synthesis reaction that did not require protection / deprotection reaction by Click-Reaction was established. At present, the labeling reaction is preparing for sequencing at the time of synthesis, label synthesis, and animal experiments.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hiroshi, Yamaguchi"}],"nameIdentifiers":[{"nameIdentifier":"1019986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamashiro, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"1019987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maki, Okada"}],"nameIdentifiers":[{"nameIdentifier":"1019988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karuo, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"1019989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Omote, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"1019990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Katsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"1019991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Yamaguchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1019992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maki, Okada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1019993","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Structural design of glutamate transporter 18F-PET agent and synthesis using a Click-Reaction","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structural design of glutamate transporter 18F-PET agent and synthesis using a Click-Reaction"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-05"},"publish_date":"2022-01-05","publish_status":"0","recid":"84496","relation_version_is_last":true,"title":["Structural design of glutamate transporter 18F-PET agent and synthesis using a Click-Reaction"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:23:29.141862+00:00"}