@misc{oai:repo.qst.go.jp:00084496,
 author = {Hiroshi, Yamaguchi and Yamashiro, Keiichi and Maki, Okada and Karuo, Yukiko and Omote, Masaaki and Kato, Katsuhiko and Hiroshi, Yamaguchi and Maki, Okada},
 month = {Dec},
 note = {Background and purpose
We excelled off-target binding using computer chemistry techniques and worked on the development of PET imaging agents that bind to glutamate transporter (GLT). Although a plurality of asymmetric carbons generated within the compound skeleton could be excluded by structure optimization, there was a problem with deprotection of the aspartic acid skeleton in the skeleton. This study aims at establishing synthesis reactions that do not require protection / deprotection reaction by Click-Reaction, recalculation of In Silico binding assay, and synthesis of obtained structural compounds.
Method
In silico binding assay we derive the predominant and ERα non-binding structure in GLT binding and have studied labeling by [18F] on synthesis and synthesizer.  In the structure reported earlier, there was a problem in deprotection of the aspartic acid skeleton in the skeleton. We examined the establishment of synthetic reactions that do not require protection / deprotection reaction by Click-Reaction.
Results and discussion
We have established a design and synthesis route for compounds excluding asymmetric positions. However, as the yield in the deprotection reaction was low, a synthesis reaction that did not require protection / deprotection reaction by Click-Reaction was established. At present, the labeling reaction is preparing for sequencing at the time of synthesis, label synthesis, and animal experiments., The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)},
 title = {Structural design of glutamate transporter 18F-PET agent and synthesis using a Click-Reaction},
 year = {2021}
}