{"created":"2023-05-15T15:02:13.325479+00:00","id":84378,"links":{},"metadata":{"_buckets":{"deposit":"d387635f-064b-45ad-968a-8247661277bb"},"_deposit":{"created_by":1,"id":"84378","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84378"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084378","sets":["11"]},"author_link":["1019034","1019033"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"345","bibliographicPageStart":"336","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Drug Delivery System"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"粒径50nmより大きなナノメディシンは膵臓がん細胞にアクセス出来ない。このことは、持続長50nmの堅さを持つ半屈曲性高分子DNAを膵臓がん細胞に送り届けることは出来ないことを示している。がん細胞を覆う線維性の間質がバリアとなっているためである。逆に言えば、50nm以下にすれば届くことを意味している。本稿では、高分子で作る遺伝子ベクターの基本的な設計指針を述べた後、堅さの起源となっている二重らせん構造を解放することでDNAを持続長以下に折りたたみ、間質を通り抜けるよう極小化する話をする。これにより、届かないの“不”が克服され、膵臓がん細胞で遺伝子発現させることが可能になる。","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"DDS学会"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長田, 健介"}],"nameIdentifiers":[{"nameIdentifier":"1019033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kensuke, Osada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1019034","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"不届を届くに. DNAを膵臓がん細胞に届ける","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"不届を届くに. DNAを膵臓がん細胞に届ける"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-24"},"publish_date":"2021-12-24","publish_status":"0","recid":"84378","relation_version_is_last":true,"title":["不届を届くに. DNAを膵臓がん細胞に届ける"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:28:14.073216+00:00"}