{"created":"2023-05-15T15:02:10.718227+00:00","id":84323,"links":{},"metadata":{"_buckets":{"deposit":"8b16d0fa-a907-4d0d-8f78-aa06c0ad0d97"},"_deposit":{"created_by":1,"id":"84323","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84323"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084323","sets":["1"]},"author_link":["1041801","1041800","1041786","1041787","1041794","1041797","1041802","1041788","1041791","1041798","1041803","1041790","1041793","1041795","1041799","1041789","1041792","1041796"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"2519","bibliographicPageStart":"2503","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Stem cell reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We here demonstrate that microsatellite (MS) alterations are elevated in both mouse and human induced pluripotent stem cells (iPSCs), but importantly we have now identified a type of human iPSC in which these alterations are considerably reduced. We aimed in our present analyses to profile the InDels in iPSC/ntESC genomes, especially in MS regions. To detect somatic de novo mutations in particular, we generated 13 independent reprogramed stem cell lines (11 iPSC and 2 ntESC lines) from an identical parent somatic cell fraction of a C57BL/6 mouse. By using this cell set with an identical genetic background, we could comprehensively detect clone-specific alterations and, importantly, experimentally validate them. The effectiveness of employing sister clones for detecting somatic de novo mutations was thereby demonstrated. We then successfully applied this approach to human iPSCs. Our results require further careful genomic analysis but make an important inroad into solving the issue of genome abnormalities in iPSCs.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34559999","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.stemcr.2021.08.017","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2213671121004355?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2213-6711","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kamimura, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"1041786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Tomo"}],"nameIdentifiers":[{"nameIdentifier":"1041787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hoki, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"1041788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunayama, Misato"}],"nameIdentifiers":[{"nameIdentifier":"1041789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imadome, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"1041790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"1041791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Miki"}],"nameIdentifiers":[{"nameIdentifier":"1041792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Ryoko"}],"nameIdentifiers":[{"nameIdentifier":"1041793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Masumi"}],"nameIdentifiers":[{"nameIdentifier":"1041794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Satoshi, Kamimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomo, Suga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuko, Fujimori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Misato, Sunayama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaori, Imadome","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mayumi, Fujita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miki, Nakamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryoko, Araki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masumi, Abe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1041803","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-27"},"publish_date":"2021-09-27","publish_status":"0","recid":"84323","relation_version_is_last":true,"title":["Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:22:29.373647+00:00"}