@article{oai:repo.qst.go.jp:00084323,
 author = {Kamimura, Satoshi and Suga, Tomo and Hoki, Yuko and Sunayama, Misato and Imadome, Kaori and Fujita, Mayumi and Nakamura, Miki and Araki, Ryoko and Abe, Masumi and Satoshi, Kamimura and Tomo, Suga and Yuko, Fujimori and Misato, Sunayama and Kaori, Imadome and Mayumi, Fujita and Miki, Nakamura and Ryoko, Araki and Masumi, Abe},
 issue = {10},
 journal = {Stem cell reports},
 month = {Sep},
 note = {We here demonstrate that microsatellite (MS) alterations are elevated in both mouse and human induced pluripotent stem cells (iPSCs), but importantly we have now identified a type of human iPSC in which these alterations are considerably reduced. We aimed in our present analyses to profile the InDels in iPSC/ntESC genomes, especially in MS regions. To detect somatic de novo mutations in particular, we generated 13 independent reprogramed stem cell lines (11 iPSC and 2 ntESC lines) from an identical parent somatic cell fraction of a C57BL/6 mouse. By using this cell set with an identical genetic background, we could comprehensively detect clone-specific alterations and, importantly, experimentally validate them. The effectiveness of employing sister clones for detecting somatic de novo mutations was thereby demonstrated. We then successfully applied this approach to human iPSCs. Our results require further careful genomic analysis but make an important inroad into solving the issue of genome abnormalities in iPSCs.},
 pages = {2503--2519},
 title = {Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells},
 volume = {16},
 year = {2021}
}