{"created":"2023-05-15T15:02:09.512400+00:00","id":84298,"links":{},"metadata":{"_buckets":{"deposit":"6c237188-0371-4bc7-a963-0f2187666b0f"},"_deposit":{"created_by":1,"id":"84298","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84298"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084298","sets":["1"]},"author_link":["1018233","1018237","1018235","1018234","1018238","1018241","1018243","1018242","1018236","1018239","1018240","1018232"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"1105","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Biomolecules"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"人工血管移植後に生じる重篤な漿液腫を予防するためには、組織との迅速な一体化（器質化）を促進することが望ましい。そこで生体内環境に類似した化学的・物理的特性を持ち、創傷治癒や器質化を促進すると考えられる量子ビーム架橋ゼラチンゲル(RXgel)を一般的なPTFE製人工血管表面に被覆する手法を開発した。vitroで繊維芽細胞の浸潤を評価するとともに、ラットへ移植して生分解速度を評価して、適切なRxgelの硬さを絞り込んだ。さらに硬さと厚みを調整したRxgel被覆人工血管をラットに移植し、14日後・28日後に組織切片を免疫染色したところ、被覆無しの従来の人工血管に比べ、αSMAやIII型コラーゲンの陽性率が高いことが分かった。Rxgel被覆人工血管の器質化促進効果により漿液腫が予防できれば、患者のQOL向上に貢献できる可能性がある。","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/biom11081105","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/2218-273X/11/8/1105","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2218-273X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuura, Sohei"}],"nameIdentifiers":[{"nameIdentifier":"1018232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takayama, Toshio"}],"nameIdentifiers":[{"nameIdentifier":"1018233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomoko, Oyama"}],"nameIdentifiers":[{"nameIdentifier":"1018234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Oyama"}],"nameIdentifiers":[{"nameIdentifier":"1018235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsumasa, Taguchi"}],"nameIdentifiers":[{"nameIdentifier":"1018236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1018237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akai, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"1018238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isaji, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"1018239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hoshina, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"1018240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomoko, Oyama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Oyama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsumasa, Taguchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018243","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Radiation-Crosslinked Gelatin Hydrogel That Promotes Tissue Incorporation of an Expanded Polytetrafluoroethylene Vascular Graft in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Radiation-Crosslinked Gelatin Hydrogel That Promotes Tissue Incorporation of an Expanded Polytetrafluoroethylene Vascular Graft in Rats"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-21"},"publish_date":"2021-07-21","publish_status":"0","recid":"84298","relation_version_is_last":true,"title":["A Radiation-Crosslinked Gelatin Hydrogel That Promotes Tissue Incorporation of an Expanded Polytetrafluoroethylene Vascular Graft in Rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:31:21.893443+00:00"}