{"created":"2023-05-15T15:02:08.630339+00:00","id":84280,"links":{},"metadata":{"_buckets":{"deposit":"ca5604fa-77b0-440d-add5-15d25dcbf816"},"_deposit":{"created_by":1,"id":"84280","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84280"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084280","sets":["10:29"]},"author_link":["1018130","1018131","1018144","1018136","1018135","1018142","1018132","1018140","1018134","1018145","1018147","1018129","1018146","1018138","1018143","1018149","1018128","1018141","1018133","1018148","1018139","1018137"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的： <SUP>18</SUP>F-PM-PBB3 PETは進行性核上性麻痺（PSP）を含む前頭側頭葉変性症（FTLD）のタウ病変を可視化するが、FTLDでは小脳にもタウが沈着しうるため、小脳以外を参照領域とした薬剤の定量が望ましい場合がある。本研究ではヒストグラムによるFTLDの参照領域の最適化を目的とした。\n方法：健常者（HC）39例、PSP患者40例および他のFTLD患者5例の<SUP>18</SUP>F-PM-PBB3 PET画像を解析した。位置合わせしたMR画像をもとに灰白質・白質のボクセル値をそれぞれヒストグラム化し、二峰性ガウス分布にフィットさせた。低い方の分布から参照領域を抽出し、小脳皮質を参照領域とした場合とそれぞれSUVR画像を作成し、鑑別能について比較した。\n結果： HCとPSP患者とで、ROC曲線に基づくAUCは灰白質（0.928）、白質（0.917）、小脳（0.908）を参照領域とした順に高かった。また他のFTLD患者においても、灰白質を参照領域とすることで、高感度に視覚評価での弁別が可能だった。\n結論：ヒストグラムを用いた参照領域の最適化は、FTLDにおける<SUP>18</SUP>F-PM-PBB3 PETの診断能を改善させる可能性がある。\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第61回に本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"互, 健二"}],"nameIdentifiers":[{"nameIdentifier":"1018128","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤, 浩信"}],"nameIdentifiers":[{"nameIdentifier":"1018129","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Debnath Oiendrila, Bhowmik"}],"nameIdentifiers":[{"nameIdentifier":"1018130","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"1018131","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松岡, 究"}],"nameIdentifiers":[{"nameIdentifier":"1018132","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑, 圭輔"}],"nameIdentifiers":[{"nameIdentifier":"1018133","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 麻衣子"}],"nameIdentifiers":[{"nameIdentifier":"1018134","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"1018135","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"1018136","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高堂, 裕平"}],"nameIdentifiers":[{"nameIdentifier":"1018137","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"1018138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Tagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hironobu, Endo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bhowmik Debnath, Oiendrila","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chie, Seki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiwamu, Matsuoka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keisuke, Takahata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maiko, Ono","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Shimada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoko, Ikoma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuhei, Takado","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1018149","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"前頭側頭葉変性症患者の18F-PM-PBB3 PET定量解析における ヒストグラムを用いた参照領域の最適化の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"前頭側頭葉変性症患者の18F-PM-PBB3 PET定量解析における ヒストグラムを用いた参照領域の最適化の検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-20"},"publish_date":"2021-12-20","publish_status":"0","recid":"84280","relation_version_is_last":true,"title":["前頭側頭葉変性症患者の18F-PM-PBB3 PET定量解析における ヒストグラムを用いた参照領域の最適化の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:32:15.131908+00:00"}