{"created":"2023-05-15T15:01:57.625197+00:00","id":84040,"links":{},"metadata":{"_buckets":{"deposit":"30f754e7-0399-43a1-8ff5-883fe86c13d7"},"_deposit":{"created_by":1,"id":"84040","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84040"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084040","sets":["1"]},"author_link":["1014967","1014973","1014975","1014974","1014976","1014966","1014971","1014972","1014970","1014968","1014969"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"109361","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Cell Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mouse embryonic stem cell (ESC) pluripotency is tightly regulated by a complex network composed of extrinsic and intrinsic factors that allow proper organismal development. O-linked β-N-acetylglucosamine (O-GlcNAc) is the sole glycosylation mark found on cytoplasmic and nuclear proteins and plays a pivotal role in regulating fundamental cellular processes; however, its function in ESC pluripotency is still largely unexplored. Here, we identify O-GlcNAcylation of proteasome activator subunit 3 (Psme3) protein as a node of the ESC pluripotency network. Mechanistically, O-GlcNAc modification of serine 111 (S111) of Psme3 promotes degradation of Ddx6, which is essential for processing body (P-body) assembly, resulting in the maintenance of ESC pluripotent state. Conversely, loss of Psme3 S111 O-GlcNAcylation stabilizes Ddx6 and increases P-body levels, culminating in spontaneous exit of ESC from the pluripotent state. Our findings establish O-GlcNAcylation at S111 of Psme3 as a switch that regulates ESC pluripotency via control of P-body homeostasis.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell "}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.celrep.2021.109361","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.cell.com/cell-reports/pdf/S2211-1247(21)00759-2.pdf","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2211-1247","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Pecori, Federico"}],"nameIdentifiers":[{"nameIdentifier":"1014966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo , Nanako"}],"nameIdentifiers":[{"nameIdentifier":"1014967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chika Ogura"}],"nameIdentifiers":[{"nameIdentifier":"1014968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Taichi"}],"nameIdentifiers":[{"nameIdentifier":"1014969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kume, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"1014970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamijima, Youhei"}],"nameIdentifiers":[{"nameIdentifier":"1014971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuo Yamamoto "}],"nameIdentifiers":[{"nameIdentifier":"1014972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishihara, Shoko"}],"nameIdentifiers":[{"nameIdentifier":"1014973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chika, Ogura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taichi, Miura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoko, Nishihara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014976","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-15"},"publish_date":"2021-07-15","publish_status":"0","recid":"84040","relation_version_is_last":true,"title":["Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:45:01.299879+00:00"}