{"created":"2023-05-15T15:01:45.906840+00:00","id":83779,"links":{},"metadata":{"_buckets":{"deposit":"26fb9e89-795f-46cc-ba1f-dcd2d22abb56"},"_deposit":{"created_by":1,"id":"83779","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83779"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083779","sets":["10:28"]},"author_link":["1010324","1010332","1010325","1010322","1010320","1010331","1010317","1010318","1010319","1010323","1010329","1010327","1010321","1010326","1010330","1010328"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[18F]フルオロメチルコリン（[18F]FCho）は、脳腫瘍や前立腺がんのイメージング剤として広く利用されている。[18F]FCho合成法は、[18F]フルオロメチルブロミドからの2ポットを用いた方法が多く行われている。我々は、汎用的な1ポット自動合成装置を用いた[18F]FCho合成を可能とするため、 [18F]フルオロメチルトシレートからの合成法を検討した。【方法】Sep-Pak QMAを用いて炭酸カリウム＋K222入り98％アセトニトリル水溶液で18F-を溶出し、1,2-ビス(トシルオキシ)メタン+炭酸セシウム入り反応容器に加え、100℃で10分間反応させた。次に、2-ジメチルアミノエタノールを加え、110℃で10分間反応させ、Sep-Pak C18及びAccell CMを用いて精製し、注射液とした。【結果】[18F]FChoは、合成時間約60分で約10%の放射化学的収率（RCY）で合成できたが、K222が40 μg/mL以上となった。K222及び炭酸カリウム量を半分にしたところ、K222量は40 μg/mL以下となったが、18F-回収量が減少し、RCYが約3%となった。【結論】[18F]FChoは、簡易的1ポット[18F]フルオロメチル化標識法により合成できた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第61回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"1010317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"1010318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 政直"}],"nameIdentifiers":[{"nameIdentifier":"1010319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塚越, 海渡"}],"nameIdentifiers":[{"nameIdentifier":"1010320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保, 崇之"}],"nameIdentifiers":[{"nameIdentifier":"1010321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"1010322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣, 信樹"}],"nameIdentifiers":[{"nameIdentifier":"1010323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"1010324","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010325","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanao, Ogawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaito, Tsukagoe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroki, Hashimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuki, Nengaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010332","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"簡易的1ポット[18F]フルオロアルキル化標識法を用いた[18F]フルオロメチルコリンの合成検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"簡易的1ポット[18F]フルオロアルキル化標識法を用いた[18F]フルオロメチルコリンの合成検討"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-15"},"publish_date":"2021-09-15","publish_status":"0","recid":"83779","relation_version_is_last":true,"title":["簡易的1ポット[18F]フルオロアルキル化標識法を用いた[18F]フルオロメチルコリンの合成検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:04:35.427960+00:00"}