{"created":"2023-05-15T15:01:45.770745+00:00","id":83776,"links":{},"metadata":{"_buckets":{"deposit":"da8ae6d9-4492-4c01-928e-f837f8822c90"},"_deposit":{"created_by":1,"id":"83776","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83776"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083776","sets":["10:28"]},"author_link":["1010253","1010260","1010258","1010261","1010259","1010254","1010248","1010257","1010262","1010250","1010255","1010256","1010251","1010252","1010249","1010263"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-11-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】 [64Cu]Cu-ATSM注射剤は脳腫瘍への治療効果が期待される日本発の放射性医薬品である。 現在まで[64Cu]Cu-ATSM注射剤製造時は三種類の試薬をそれぞれ単独のGSフィルタに通して無菌アイソレーター内に導入し製剤化を行っていたが、今回、三種類の試薬を直接混合した後ＧＶフィルタを用いることで製剤化が可能となるか検討した。【方法】ATSM/DMSO溶液 (0.025mg/0.2mL)、64Cu/グリシン溶液 (15.1GBq/8mL)とアスコルビン酸Na液(45mg/8mL) を混合後GVフィルタを通じて無菌アイソレーターに導入し、品検、保管バイアルへの分注作業を行なった。【結果】[64Cu]Cu-ATSM注射剤は8.9GBq/11.2mL、回収率は83.7%で、注射剤のGVフィルタへの吸着も ほとんどなく、品質検査も問題なかった。また作業時間は10分間短縮し、フィルタ完全性試験は１回となった。【結論】[64Cu]Cu-ATSM注射剤製造時にＧＶフィルタを使うことでより簡便になった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第61回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武井, 誠"}],"nameIdentifiers":[{"nameIdentifier":"1010248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 寿"}],"nameIdentifiers":[{"nameIdentifier":"1010249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"深田, 正美"}],"nameIdentifiers":[{"nameIdentifier":"1010250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"1010251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"破入, 正行"}],"nameIdentifiers":[{"nameIdentifier":"1010252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"1010253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井, 幸恵"}],"nameIdentifiers":[{"nameIdentifier":"1010254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"1010255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Takei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Suzuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masami, Fukada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroki, Hashimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukie, Yoshii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1010263","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"無菌アイソレーターを用いたがん治療薬[64Cu]Cu-ATSM注射液の効率的製造","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"無菌アイソレーターを用いたがん治療薬[64Cu]Cu-ATSM注射液の効率的製造"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-07"},"publish_date":"2021-10-07","publish_status":"0","recid":"83776","relation_version_is_last":true,"title":["無菌アイソレーターを用いたがん治療薬[64Cu]Cu-ATSM注射液の効率的製造"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:04:48.063878+00:00"}