@misc{oai:repo.qst.go.jp:00083580, author = {Kenshi, Suzuki and Kazuhiro, Daino and Takamitsu, Morioka and Shizuko, Kakinuma and Kenshi, Suzuki and Kazuhiro, Daino and Takamitsu, Morioka and Shizuko, Kakinuma}, month = {Sep}, note = {Especially, after the accident at TEPCO's Fukushima Daiichi Nuclear Power Station, there are concerns about cancer risks due to low-dose radiation exposure. However, since the risk is overwhelmingly smaller than the risk due to lifestyle-related factors such as smoking, it is difficult to accurately evaluate it by an epidemiological method in which bias tends to be a problem. Therefore, the purpose of this study is to analyze the risk of lung cancer by low-dose-rate radiation. In this study, we initially analyzed the risk of lung cancers in B3C3F1 mice irradiated with gamma-rays at high-dose-rate (30 Gy/hour, total doses of 200 mGy to 4 Gy). A dose-dependent increase in the incidence of lung adenocarcinoma was observed. Interestingly, by pathological analysis, we found frequent occurrence of nuclear grooves (one of the nuclear atypia) in lung cancer cells from gamma-irradiated group compared with that of non-irradiated group. Currently, we are analyzing the risk for lung cancers in mice irradiated with low dose rate (6 mGy/hour) of gamma-rays. These results will be presented at the conference., 第64回日本放射線影響学会}, title = {Lung cancer risk in mice after low-dose-rate irradiation}, year = {2021} }